枳术党参颗粒肠推进和镇吐作用的实验研究  

Experimental study of zhizhu dangshen granules on intestinal propulsive function and antemtic effect

作　　者：张艳[1] 王宇翎[1] 吴文宁[1] 李前进[1] 林杰[1] 朱韬[1] 罗欢[1] 

机构地区：[1]安徽医科大学基础医学院药理学教研室,合肥230032

出　　处：《安徽医科大学学报》2015年第9期1286-1289,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽高校省级自然科学研究项目(编号:KJ2012A176)

摘　　要：目的观察枳术党参颗粒的肠推进和镇吐作用。方法采用阿托品、多巴胺以及肾上腺素诱导肠功能低下小鼠模型,研究枳术党参颗粒的肠推进作用;通过硫酸铜和顺铂诱导的家鸽呕吐模型,观察枳术党参颗粒的镇吐作用。结果枳术党参颗粒20 g/kg 1次给药能提高由阿托品抑制的小鼠肠推进活动,枳术党参颗粒10、20 g/kg 3次预防给药能提高多巴胺和肾上腺素抑制的小鼠肠推进活动;枳术党参颗粒16 g/kg 1次给药能减少硫酸铜所致家鸽的呕吐次数,枳术党参颗粒(4、8、16 g/kg)3次给药对顺铂所致家鸽的呕吐无明显作用。结论枳术党参颗粒有明显的促进小鼠肠排空作用,对外周呕吐有一定的镇吐作用。Objective To study the temtic effect in animals. Methods effects of zhizhu dangshen granules The models of intestinal dysfunction on intestinal propulsive function and an- induced by atropine, dopamine and epi- nephrine in mice were used to study gastrointestinal propulsive function. The models of vomit induced by copper sulfate and cisplatin in pigeon were used to study antemtic effect. Results A single administration of Zhizhu dang- shen granules （20 g/kg） could alleviate inhibition of intestinal propulsive function induced by atropine in mice. Three preventive administration of Zhizhu dangshen granules （10 g/kg and 20 g/kg） could improve the inhibition of intestinal propulsive function induced by dopamine and epinephrine in mice. A single administration of Zhizhu dangshen granules （16 g/kg） could reduce the vomitive times induced by copper sulfate in pigeon. Three preven- tive administration of Zhizhu dangshen granules （4 g/kg, 8 cisplatin in pigeon. Conclusion Zhizhu dangshen granules also has certain antiemetic effect on peripheral vomit. g/kg and 16 g/kg） had no effect on vomit induced by significantly increases intestinal propulsive function. It

关 键 词：枳术党参颗粒 肠推进作用 镇吐作用 

分 类 号：R965.2[医药卫生—药理学]