氯沙坦钾对原发性高血压伴高尿酸血症的临床研究  

Clinical effect of losartan potassium on hypertension with hyperuricemia

作　　者：袁芳[1] 王立新[2] 高金钗 杨霈龙 

机构地区：[1]河北北方学院研究生学院,河北张家口075000 [2]河北北方学院附属第一医院老年病科,河北张家口075000 [3]河北医科大学研究生学院,石家庄050011

出　　处：《中国临床药理学杂志》2015年第16期1566-1568,共3页The Chinese Journal of Clinical Pharmacology

基　　金：河北省科技计划基金资助项目(142777111D)

摘　　要：目的评价氯沙坦钾与坎地沙坦酯治疗原发性高血压合并高尿酸血症的临床疗效。方法 80例原发性高血压合并高尿酸血症患者随机分为试验组40例和对照组40例,试验组口服氯沙坦钾50 mg·d-1,对照组口服坎地沙坦酯8 mg·d-1,2组疗程均为8周,比较2组患者治疗前后血尿酸和血压变化。结果与治疗前比较,试验组和对照组治疗后收缩压和舒张压的下降幅度分别为18.95/12.70 mm Hg和27.18/13.03 mm Hg,差异有统计学意义(P<0.05)。试验组降压总有效率为92.5%,对照组总有效率为95.0%,差异无统计学意义(P>0.05)。试验组治疗后血尿酸水平为(431.98±56.11)μmol·L-1,较治疗前的(495.29±51.04)μmol·L-1明显降低(P<0.05)。对照组治疗前后血尿酸水平(486.79±60.81),(470.66±79.36)μmol·L-1差异无统计学意义(P>0.05)。试验组治疗前后血尿酸水平变化与收缩压水平变化呈正相关(r=0.366,P<0.05)。结论氯沙坦钾对原发性高血压伴高尿酸血症患者降压和降尿酸效果显著。Objective To observe the clinical effect of losartan potassium and candesartan in the treatment of hypertension with hyperuricemia. Methods Total of eighty patients diagnosed with hypertension with hyperuricemia were randomly divided into two groups. The patients in experiment group（ n = 40） were given losartan potassium 50 mg · d^- 1,and the control group（ n = 40） were given candesartan 8 mg · d^- 1. The treatment lasted for 8 weeks. Serum uric acid levels and blood pressure levels were measured before and after treatment respectively. Results After treatment,the reduction of systolic blood pressure（ SBP） and diatolic blood pressure（ DBP） were18. 95 /12. 70 mmHg vs 27. 18 /13. 03 mmHg in experiment and control group（ P〈0. 05）. The overall effective rations of experiment group and control group were not significant（ 92. 5% vs 95. 0%,P〉0. 05）. After treatment,the level of uric aciddecreased apparently in experiment group[（ 431. 98 ± 56. 11） vs（ 495. 29 ± 51. 04） μmol · L^- 1,P〈0. 05].There was no significance in uric acid level before and after treatment in control group [（ 486. 79 ± 60. 81） vs（ 470. 66 ± 79. 36） μmol · L^- 1,P〉 0. 05]. There was a positive correlation between the range of uric acid level and the decrease of systolic blood pressure level（ r = 0. 366,P〈0. 05） in experiment group. Conclusion Losartan potassium is more useful than candesartan for hypertension with hyperuricemia.

关 键 词：氯沙坦 原发性高血压 坎地沙坦 血尿酸 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]