复方前列安颗粒治疗慢性无菌性前列腺炎大鼠的药效学研究  

Study on pharmacodynamics of Compound Qianliean Granule in the treatment of chronic nonbacterial prostatitis in rats

作　　者：李小莉[1] 蓝献全 潘素珍[1] 

机构地区：[1]新丰县中医院药剂科,广东新丰511100 [2]韶关市食品药品检验所,广东韶关512028

出　　处：《中国临床药理学杂志》2015年第16期1656-1658,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的研究复方前列安颗粒治疗慢性无菌性前列腺炎大鼠的药效学。方法按照体重随机将大鼠分为3组,实验组(给予3.0 g·kg-1复方前列安颗粒)、对照组(给予2.4 g·kg-1前列舒乐颗粒)及正常组(给予蒸馏水),每日1次。给药7 d后,镜下观察大鼠白细胞计数、卵磷脂小体密度的差异,用左、右耳片重量之差计算肿胀度,比较深入腹腔染料量的差异。结果实验组,白细胞数明显低于对照组和正常组,卵磷脂小体密度明显高于对照组和正常组(均P<0.05);实验组、对照组与正常组的肿胀度和光密度比较,差异有统计学意义(P<0.05)。结论复方前列安颗粒对慢性无菌性前列腺炎症具有良好的抑制作用。Objective To explore the efficacy of Compound Qianliean Granule in the treatment of chronic nonbacterial prostatitis study in rats.Methods The rats were randomly divided into three groups,experimental group（ treated with 3. 0 g · kg^- 1Compound Qianliean Granule） and control group（ treated with 2. 4 g · kg^- 1Qianlieshule granule） and normal group（ treated with distilled water）, 1 times daily. The difference of white blood cell count, lecithin corpuscle density were observed after 7 days administration by microscope. The difference of left and right ear weight was calculated on the degree of swelling. The differences of quantity in abdominal cavity dye of relatively deep was compared. Results The white blood cell count in experimental group was significantly higher than that of the control group and the normal group. The lecithin corpuscle density as compared with the control group and the normal group, the difference is statistically significant（ P〈0. 05）. The difference of swelling degree and the absorbance compared between experimental group,control group and normal group were significant（ P〈0. 05）. Conclusion Compound Qianliean Granule has good inhibitory effect on chronic abacterial prostatitis.

关 键 词：复方前列安颗粒 慢性无菌性前列腺炎 药效学 

分 类 号：R285.5[医药卫生—中药学] R965.1[医药卫生—中医学]