阳江市健康人群麻疹疫苗免疫和抗体水平调查分析  

Analysis on the Measles Vaccine Immunization Status and Ig G Antibody Level of Healthy Population in Yangjiang City

作　　者：范子凡 利定良 吴其婷[1] 冯荣添 戴伯宏 敖艳云 林露[1] 

机构地区：[1]广东省阳江市疾病预防控制中心,广东阳江529500

出　　处：《中国医学创新》2015年第24期61-64,共4页Medical Innovation of China

基　　金：阳江市医疗卫生类科技计划项目(阳科通[2015]5号)

摘　　要：目的:了解阳江市健康人群麻疹疫苗免疫状况和Ig G抗体水平,为控制和消除麻疹提供参考依据。方法:采取分层随机抽样的方法,在辖区内共抽取20个乡镇,每个乡镇调查≥48个健康人,用酶联免疫吸附试验检测麻疹Ig G抗体。结果:麻疹疫苗免疫率为87.11%,抗体阳性率为80.28%,抗体保护率为39.72%,抗体几何平均滴度(GMT)为1∶570.72。在麻疹抗体阳性率、保护率、GMT中,不同年龄组和不同地区的差异均有统计学意义。不同性别阳性率和保护率的差异均有统计学意义,GMT差异无统计学意义。有免疫史的人群中,阳性率差异有统计学意义,保护率和GMT的差异均无统计学意义。无免疫史与接种3剂次以上人群的麻疹抗体阳性率差异无统计学意义,两类人群的保护率和GMT各自的差异有统计学意义。结论:阳江市健康人群的麻疹抗体未能形成有效的免疫屏障,应加强复种,倡导接种含麻疹成分联合疫苗。Objective： To understand the immune status of measles vaccine and IgG antibody level in healthy population in Yangjiang city and to provide reference for controlling and eliminating measles.Method： More than or equal to 48 healthy people were investigated in each township by stratified random sampling method in a total 20 townships, measles IgG antibody were detected by using enzyme linked immunosorbent test.Result：The measles vaccine immunization rate was 87.11%, the positive rate of antibody was 80.28%, the antibody protection rate was 39.72%, and the geometric mean titer （ GMT ） of antibody was l ： 570.72. In different age groups and different regions, the positive rate of measles antibody, protective rate and GMT were statistically significant. There were significant differences in the positive rate and the protection rate among different gender groups, and the difference of GMT was not statistically significant. There was significant difference in the positive rate among the population with immune history, hut the difference of protection rate and GMT was not statistically significant.There was no significant difference in the positive rate of measles antibody in the population with no immunity history and the 3 doses vaccination.Conclusion： The healthy population in Yangjiang city of measles antibodies failed to form an effective immune barrier and should be strengthen the multiple cropping, advocating vaccination with measles containing vaccine.

关 键 词：麻疹 免疫率 阳性率 保护率 几何平均滴度 

分 类 号：R186[医药卫生—流行病学]