影响糖尿病患者胃动力学的因素  

Factors influencing gastric dynamics in diabetes patients

作　　者：赵宏[1] 李卉[2] 辛忠秋[1] 杜娟[1] 高惠娟[1] 付鸿玉[1] 姜海红[1] 

机构地区：[1]黑龙江大庆油田总医院内分泌科,黑龙江省大庆市163001 [2]中国医科大学附属盛京医院内科,辽宁省沈阳市110004

出　　处：《世界华人消化杂志》2015年第21期3486-3490,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨糖尿病患者胃动力学的影响因素.方法:采用半流质核素胃排空试验方法,对黑龙江大庆油田总医院2013-02/2014-08收治的120例糖尿病患者的临床资料进行胃动力学分析,将患者分为两组,胃动力异常组和胃动力正常组,每组60例.了解患者年龄、血糖水平、病程、血浆胰岛素、糖化血红蛋白A1c(hemoglobin,HbA1c)、体质量指数(body mass index,BMI)、胃泌素、胃动素、胰升糖素以及镁离子浓度等水平和含量,并做好记录.结果:120例糖尿病患者中,74例胃排空延迟,占61.67%;胃动力异常组患者病程、年龄、血糖水平以及HbA1c明显高于胃动力正常组(P<0.05);而胃动力异常组患者的胃动力素水平、胰岛素以及BMI水平明显低于胃动力正常组(P<0.05);两组患者的胰升糖素、胃泌素以及血镁水平差异没有无统计学意义(P>0.05);有残余尿者GE比正常对照组均有明显延迟(P<0.05).结论:糖尿病胃动力异常是在多种因素共同作用下形成的,胃动力异常与患者年龄、病程、血糖水平、胰岛素、胃动素、HbA1c、BMI等有密切的联系.临床上早期进行胃排空试验,能够早期诊断此病,提高治疗效果.AIM： To identify the factors influencing gastric dynamics in patients with diabetes. METHODS： One hundred and twenty diabetes patients who underwent gastric dynamicsanalysis from February 2018 to August 2014 at Heilongjiang Daqing Oil Field General Hospital were divided into two groups, patients with abnormal gastric dynamics and those with normal gastric dynamics （n = 60 each）. Patient age, plasma insulin and blood sugar levels, disease course, glycosylated hemoglobin Alc （HbAlc）, body mass index （BMI）, gastrin, motilin, glucagon, and magnesium were compared for the two groups. RESULTS： Of the 120 diabetic patients, 74 （61.67%） had delayed gastric emptying. Age, duration of disease, blood glucose and HbAlc levels were significantly higher in the abnormal gastric dynamic group than in the normal gastric dynamic group （P 〈 0.05）. Motilin, plasma insulin and BMI were significantly lower in the abnormal gastric dynamic group than in the normal gastric dynamic group （P 〈 0.05）. There was no significant difference in glucagon, gastrin, or magnesium between the two groups （P 〉 0.05）. CONCLUSION： The development of abnormal gastric dynamics in diabetes patients is multifactorial, and age, course of disease, blood glucose, insulin, motilin, HbAlc, and BMI may be influencing factors.

关 键 词：糖尿病 胃动力学 影响 

分 类 号：R587.1[医药卫生—内分泌]