ACS患者细胞因子变化对粥样斑块不稳定性的预测价值  

Value of cytokines for predicting atheromatous plaque instability in patients with ACS

作　　者：何如平[1] 叶健烽[1] 张晓明[1] 简政威[1] 黄志超[1] 李大强[1] 

机构地区：[1]广东东莞市人民医院心血管内科,广东东莞523000

出　　处：《海南医学院学报》2015年第9期1182-1184,共3页Journal of Hainan Medical University

基　　金：广东省东莞市科技计划医疗卫生类科研项目(201110515001085)~~

摘　　要：目的:分析急性冠状动脉综合征(ACS)患者血清中的白介素-6(IL-6)、白介素-10(IL-10)、IL-6/IL-10、肿瘤坏死因子-α(TNF-α)与超敏C-反应蛋白(hs-CRP)的含量变化与粥样斑块不稳定性的相关性,探讨其的临床预测价值。方法:选取于本院行冠状动脉造影术(CAG)患者240例,其中188例确诊为ACS患者根据诊断结果将其分为急性心肌梗死(AMI组)106例,不稳定性心绞痛(UA组)82例;CAG检查阴性患者52例设为对照组。采用酶联免疫法(ELISA)测定各组血清中IL-6、IL-10、IL-6/IL-10、TNF-α与hs-CRP的含量,并进行统计学分析。结果:观察组的血清中IL-6、IL-10、TNF-α含量、IL-6/IL-10比值均明显高于对照组,差异具有统计学意义(P<0.05);观察组的血清IL-6含量与hs-CRP含量呈正相关的关系(P<0.05);IL-6含量与TNF-α含量呈正相关的关系(P<0.05)。结论:ACS患者血清IL-6/IL-10比值、TNF-α及hs-CRP的含量与ACS的病症具有一定相关性,有对粥样斑块不稳定性的临床预测具有一定价值。Objective：To analyze the correlation between changes in serum interleukin 6（IL 6）,interleukin 10（IL-10）,IL-6/IL-10,tumor necrosis factor alpha（TNF alpha）and allergic C-reactive protein（hs CRP）levels and the atheromatous plaque instability in patients with ACS in order to explore the predictive value of these cytokines.Methods：A total of 240 cases scheduled for coronary arteriography（CAG）were enrolled,of which 188 patients were confirmed as ACS including 106 cases of acute myocardial infarction（AMI）,82 cases of unstable angina（UA）;and 52 negative cases were assigned as control group.Serum IL-6,IL-10,IL-6/IL-10,the TNF alpha and hs-CRP contents were determined with enzyme-linked immunoassay（ELISA）.Results：Serum IL-6,IL-10,IL-6/IL-10,the TNF alpha and hs-CRP contents of the observation group were significantly higher than that of control group（P〈0.05）;As for the observation group,content of serum IL-6and hs-CRP levels were positively correlated（P〈0.05）;content of I-6and TNF alpha levels were positively correlated too（P〈0.05）.Conclusion：For ACS patients,serum IL-6/IL-10 ratio,TNF alpha and hs-CRP were correlated with the disease indicating it has value for predicting atheromatous plaque instability in patients with ACS.

关 键 词：急性冠状动脉综合征 细胞因子 粥样斑块不稳定性 预测价值 

分 类 号：R541.4[医药卫生—心血管疾病]