活性氧在骨性关节炎发病中的作用机制（英文）  

The role of reactive oxygen species in osteoarthritis pathogenesis

作　　者：丁舒晨 秦子力 尹战海[1] 邱裕生[1] 

机构地区：[1]西安交通大学医学部第一附属医院骨科,中国710061

出　　处：《中国矫形外科杂志》2015年第17期1587-1590,共4页Orthopedic Journal of China

基　　金：National Natural Science Foundation of China(81371943,30801173);Long Schooling Medical Students Clinical Innovation Fund of First Hospital of Xi’an Jiaotong University(14ZD10);Fundamental Research Funds for the Central Universities

摘　　要：近年来越来越多的研究表明活性氧在骨性关节炎的发病中起到关键作用,主要涉及到软骨细胞的凋亡和细胞外基质的退化,后者包括基质合成减少、分解增加以及钙化形成。本文就活性氧在骨性关节炎发病机制研究中的进展作一综述。Recently, a growing body of evidence suggests that reactive oxygen species play a critical role in the pathogenesis of osteoarthritis, especially with regard to chondrocyte apoptosis and cartilage extra cellular ma- trix degeneration, which includes decreased matrix anabolism, increased catabolism and calcification forma- tion. The purpose of this review is to examine ROS overexpression in relation to OA pathogenesis.

关 键 词：骨性关节炎 活性氧 凋亡 基质退化 

分 类 号：R684.3[医药卫生—骨科学]