国内多中心甲真菌病病原菌流行病学调查  

Multi-center epidemiological survey of pathogenic fungi of onychomycosis in China

作　　者：王爱平[1] 余进[1] 万喆[1] 李福秋[2] 曾敬思[3] 刘维达[4] 章强强[5] 郝飞[6] 冉玉平[7] 席丽艳[8] 赖维[9] 李若瑜[1] 

机构地区：[1]北京大学第一医院皮肤性病科,北京100034 [2]吉林大学第二医院皮肤科,长春130041 [3]华中科技大学同济医学院附属协和医院皮肤科,武汉430022 [4]中国医学科学院北京协和医学院皮肤病研究所真菌科,南京210042 [5]复旦大学附属华山医院皮肤科,上海200040 [6]第三军医大学第一附属医院皮肤科,重庆400038 [7]四川大学华西医院皮肤科,成都610041 [8]中山大学孙逸仙纪念医院皮肤科,广州510120 [9]中山大学附属第三医院皮肤科,广州510630

出　　处：《中国真菌学杂志》2015年第4期197-202,共6页Chinese Journal of Mycology

摘　　要：目的了解国内甲真菌病病原菌的种类和构成情况,掌握流行病学资料。方法对真菌镜检阳性的1 428例甲真菌病患者进行真菌培养和临床分析。结果真菌培养阳性率为53.9%,分离出病原菌800株。其中皮肤癣菌占84.0%,以红色毛癣菌为主(80.9%),其次为指(趾)间毛癣菌和絮状表皮癣菌。酵母菌占11.4%,以念珠菌属为主(10.1%),尤以近平滑念珠菌为主,其次为白念珠菌和热带念珠菌。其他霉菌占4.6%,以枝顶孢霉为主(2.3%),其次曲霉属、青霉属、毛壳菌属、镰刀菌属和帚霉属等。结论本研究显示甲真菌病病原菌以皮肤癣菌为主,其次为酵母菌和霉菌。Objective The aim of this study was to investigate the epidemiology of pathogenic fungi of onychomycosis in China.Methods Fungal culture and clinical analysis were performed on 1 428 cases of onychomycosis using positive direct microscopic examination.Results Eight hundred strains were isolated, the positive rate was 53.9%.The most frequently isolated fungi were dermatophytes （84%）, Trichophyton rubrum accounted for 80.9%, followed by Trichophyton interdigitale and Epidermophyton floccosum. The second was yeasts （11.4%）, Candida accounted for 10.1%, mainly included C.parapsilosis, C.albicans and C.tropicalis.Non-dermatophytic moulds accounted for 4.6%, included Acremonium, Aspergillus, Penicillium, Chaetomium, Fusarium and Scopulariopsis.Conclusion In China, the most frequently pathogenic fungi of onychomycosis were dermatophytes, followed by yeasts and non-dermatophytic moulds.

关 键 词：甲真菌病 病原菌 多中心 流行病学研究 

分 类 号：R756.4[医药卫生—皮肤病学与性病学]