硝酸舍他康唑的临床应用研究进展  

Advances in the clinical application of sertaconazole nitrate

作　　者：孙玉鲁[1] 张锐利[1] 苏芳[1] 

机构地区：[1]威海市立医院皮肤美容科,威海264200

出　　处：《中国真菌学杂志》2015年第4期252-256,共5页Chinese Journal of Mycology

摘　　要：硝酸舍他康唑(sertaconazole)是一种新型、广谱、高效的外用唑类抗真菌药。本文就其药理作用、抗炎、止痒、抗真菌临床疗效及安全性评价等方面加以综述。新的剂型-微乳凝胶,增强皮肤渗透性和存留时间,而且能减少对皮肤的刺激。外用硝酸舍他康唑治疗皮肤癣菌病和浅表念珠菌感染见效快,治愈率高,疗程短。根据药代动力学,舍他康唑只需每日用药一次,加之其止痒活性,增加了患者依从性,从而提高了临床治愈率。最新临床研究发现外用硝酸舍他康唑乳膏对脂溢性皮炎、特应性皮炎有良好的疗效。Sertaconazole nitrate is a new broad-spectrum, efficient topical azole antifungal.This paper summarizes its pharmacological action, anti-inflammatory, antipruritic action, antifungal activity, the latest clinical efficacy and safety evaluation in the treatment of dermatophytoses, superficial candidiasis, seborrheic dermatitis and atopic dermatitis etc.Compared with miconazole, clotrimazole, terbinafine etc, sertaconazole cream can provide a better efficacy and tolerability in the treatment of skin tinea and superficial Candidal infections.Its antipruritic action and once-daily application in the light of its pharmacokinetics increase patient adherence and the cure rate.A topical microemulsion-based hydrogel has been developed to enhance permeation of sertaconazole for effective eradication of cutaneous fungal infection.The latest clinical studies suggest that sertaconazole cream may be an excellent alternative therapeutic modality for treating seborrheic dermatitis and atopic dermatitis.

关 键 词：硝酸舍他康唑 抗真菌药 皮肤癣菌病 浅表念珠菌病 脂溢性皮炎 特应性皮炎 

分 类 号：R978.5[医药卫生—药品]