血清同型半胱氨酸与胱抑素C在妊高症患者中的变化及临床价值分析  

The analysis of serum homocysteine and bladder inhibition C in patients with pih and clinical value

作　　者：张允奇[1] 张银辉[2] 陆学东[2] 何涛君[2] 罗秀霞[1] 

机构地区：[1]广东医学院附属深圳市福田医院香蜜湖分院检验科,深圳518033 [2]广东医学院附属深圳市福田医院检验医学部,深圳518033

出　　处：《北方药学》2015年第9期86-87,共2页Journal of North Pharmacy

摘　　要：目的：探讨血清同型半胱氨酸（HCY）与胱抑素C（Cys-c）在不同程度妊高症患者中的临床变化规律及其诊断意义。方法：选取2011年1月-2014年1月间于我院确诊并接受治疗的妊娠高血压患者180例作为观察组研究对象,按照患者病情严重程度分为轻度观察组、中度观察组以及重度观察组,每组患者60例,另外选取正常妊娠健康产妇60例作为对照组,检测各组患者的血清同型半胱氨酸（HCY）与胱抑素C（Cys-c）的指标值。结果：经过检验,观察组患者的血清同型半胱氨酸（HCY）与胱抑素C（Cys-c）含量明显高于对照组,而在观察组中,中度观察组血清同型半胱氨酸（HCY）（25.98±0.75）与胱抑素C（Cys-c）（1.88±0.31）含量明显高于轻度观察组（19.03±0.69）、（1.32±0.35）患者,而重度观察组两项指标分别为（36.21±1.56）、（2.53±0.5）含量却明显高于中度组,各组统计结果均具有明显性差异（P〈0.05）,治疗后,各组患者的血压明显降低,而血清同型半胱氨酸（HCY）与胱抑素C（Cys-c）含量也明显低于治疗前。结论：血清同型半胱氨酸和胱抑素C的检测对了解妊娠期高血压疾病患者具有重要意义,并以此可作为预测妊高征的发生以及判断病情轻重的重要指标,其对妊娠高血压的诊断、病情发展以及预后效果都具有明显意义。Objective： To explore the serum homocysteine （HCY） and C inhibition （Cys - C） in the different degree of pih patients clinical change rule and its diagnostic significance. Methods： Selected 180 cases of pregnancy-induced hypertension patients from January 2011 to January 2011 in our hospital as the research object, and then were divided into mild group and moderate group and severe group according to the severity, there were 60 cases patients in each group, while selected maternal health 60 casesof normal pregnancy as control group, test serum homoeysteine （HCY） and urinary inhibition C （Cys - C） index of different groups patients. Results： Through inspection, serum homocysteine （HCY） and urinary inhibition （Cys - C）C content of observation group was significantly higher than the control group, while in the observation group, moderate group serum homocysteine （HCY） urinary inhibition （25.98±0.75）and C （Cys - C）,（ 1.88±0.31 ）content is significantly higher than the mild group （19.03±0.69）, （1.32±0.35）,Both patients and severe group, respectively （36.21±1.56）, （2.53±0.5） content was significantly higher than moderate groups, each group statistical results have obvious difference （P〈O.05）, after treatment, the patient＇s blood pressure significantly decreased, and serum homocysteine （HCY） and urinary inhibition （Cys - C）C content is significantly lower than before treatment. Conclusion： The serum homoeysteine and the oboro inhibition of C detection is of great significance to understand the patients with gestational hypertension disease, which can be used as predicting the occurrence of pregnancy, high character and judge illness weight important indicators, the diagnosis, disease progression and prognosis of gestational hypertension effect has obvious significance.

关 键 词：血清同型半胱氨酸 胱抑素C 妊高症 变化 临床价值 

分 类 号：R714.246[医药卫生—妇产科学]