胎儿纤维连接蛋白与宫颈长度联合预测早产的临床效果研究  

The study of clinical effects of fFN combined with CL for abortive prediction

作　　者：罗敏 

机构地区：[1]广东省河源市妇幼保健院妇产科,广东河源517000

出　　处：《中国医药科学》2015年第14期10-12,37,共4页China Medicine And Pharmacy

基　　金：广东省河源市科技计划项目(2013-039)

摘　　要：目的 探讨胎儿纤维连接蛋白（fFN）与宫颈长度联合检测在预测早产的临床应用价值。方法 选取2010年1月~2014年5月我院产科收治的92例先兆早产孕妇为观察组,其孕周均为22~35周。对92例患者均行阴道后弯窿分泌物fFN测定及阴道B超测量宫颈长度。结果 （1）92例先兆早产孕妇中f FN阳性40例,其中32例早产,阴性孕妇52例,其中7例早产。fFN阳性与fFN阴性组间的早产率有显著性差异,fFN阳性组早产率显著高于阴性组（P〈0.05）。其预测孕37周前发生早产的敏感度、特异性度、阳性预测值、阴性预测值分别为100.0%、90.4%、32.9%、100.0%。（2）92例先兆早产孕妇中阴道超声检测宫颈长度≤30mm者42例,其中32例早产,〉30mm孕妇50例,其中7例早产。CL≤30mm组与CL〉30mm组两组间的早产率有显著性差异,CL≤30mm早产率显著高于CL〉30mm组（P〈0.05）。其预测孕37周前发生早产的敏感度、特异性度、阳性预测值、阴性预测值分别为100.0%、98.2%、66.9%、100.0%。（3）92例先兆早产孕妇中fFN阳性或CL阳性者56例,其中53例早产,fFN阴性且CL阴性者36例,均未出现早产,两组间的早产率有显著性差异,fFN阳性或CL阳性组早产率显著高于fFN阴性且CL阴性（P〈0.05）。二者联合检测预测孕37周前发生早产的敏感度、特异性度、阳性预测值、阴性预测值均达到100.0%。结论 fFN与CL均在预测中具有较高应用价值,二者联合应用可显著提高敏感度、特异性度、阳性预测值、阴性预测值。Objective To study the clinical application value of fFN combined with CL for abortive prediction. Methods 92 pregnant women with threatened premature labor for 22-35 gestational weeks treated from January 2010 to May 2014 in our hospital were selected. The detections of excreta fFN in posterior fornixs of vagina and CL based on B ultrasound were conducted. Results （1） There were 40 fFN positive cases including 32 cases with premature delivery; And there were 52 fFN negative cases including 7 cases with premature delivery. The rate of premature delivery of fFN positive group was significantly higher than that of fFN negative group（P 〈 0.05）; Before 37w, the sensitivity, specificity, positive predictive value and negative predictive value were 100.0%, 90.4%, 32.9% and 100.0% respectively. （2） Based on B ultrasound, there were 42 cases（CL ≤ 30mm） including 32 cases with premature delivery; There were 50 cases （CL 〉 30mm） including 7 cases with premature delivery. The rate of premature delivery between two groups was significantly different （P 〈 0.05）; before 37w, the sensitivity, specificity, positive predictive value and negative predictive value werel00.0%, 98.2%, 66.9% and 100.0%.（3） There were 56 fFN positive or CL positive cases including 53 cases with premature delivery; there were 36 fFN negative or CL negative cases. The rate of premature delivery between two groups was significantly different （P 〈 0.05）. Before 37w, the sensitivity, specificity, positive predictive value and negative predictive value based on combined detection methods were 100.0%. Conclusion fFN and CL have a higher application value in abortive prediction. The combined methods can improve the sensitivity, specificity, positive predictive value and negative predictive value greatly.

关 键 词：胎儿纤维连接蛋白 宫颈长度 联合 早产预测 

分 类 号：R714.21[医药卫生—妇产科学]