组织型纤溶酶原激活剂治疗儿童塑型性支气管炎的疗效  

Clinical study of tissue - type plasminogen activator therapy for children＇ s plastic bronchitis

作　　者：郭伟[1] 徐勇胜[1] 万莉雅[1] 陈晓颖[1] 宁静[1] 卢鸣[1] 刘福军[1] 

机构地区：[1]天津市儿童医院呼吸科,300074

出　　处：《中华实用儿科临床杂志》2015年第16期1233-1235,共3页Chinese Journal of Applied Clinical Pediatrics

摘　　要：目的分析组织型纤溶酶原激活剂（tPA）治疗儿童塑型性支气管炎（CB）的临床疗效。方法收集天津市儿童医院2013年9月至2015年1月住院并通过支气管镜局部使用tPA治疗的CB患儿资料，分析tPA的治疗效果及安全性，包括患儿的临床表现、影像学改变及随访情况。结果所有患儿经支气管镜介入及tPA治疗后均取出大量的塑型物质，临床表现包括呼吸、体温、经皮测血氧饱和度及影像学改变均有明显改善，安全性良好。结论支气管镜是治疗CB的有效方法，配合使用tPA能够取得更好的临床疗效，该方法安全有效，宜在疾病发生的早期应用，以防止严重的呼吸道阻塞等并发症发生。Objective To evaluate the clinical efficacy of tissue-type plasminogen activator （tPA） treatment of children with plastic bronchitis. Methods The study retrospectively reviewed the clinical data of the children with plastic bronchitis who were admitted to Tianjin Children＇s Hospital from September 2013 to January 2015 and were trea- ted with tissue - type plasminogen activator. This study analyzed the effect and safety of tPA treatment,including clini- cal and radiological changes and follow - ups . Results A lot of plastic secretions were safely removed from the bron- chial tubes in all children and clinical manifestations including breathing, body temperature, transcutaneous oxygen satu- ration and image changes were significantly improved. Conclusions Bronchoscopy is an effective way to treat plastic bronchitis, but with the use of tPA a better clinical efficacy could be achieved. The method is safe and effective and should be applied early in the patients in order to prevent the occurrence of severe airway obstruction complications.

关 键 词：塑型性支气管炎 纤维素性支气管炎 支气管镜 组织型纤溶酶原激活剂 儿童 

分 类 号：R725.6[医药卫生—儿科]