小儿诺如病毒性肠炎的临床特征  

Prevalence and Characterization of Norovirus in Children and Infants with Sporadic Acute Gastroenteritis

作　　者：夏嘉陵[1] 万朝敏[2] 朱渝[2] 

机构地区：[1]攀枝花市妇幼保健院,四川攀枝花617000 [2]四川大学华西第二医院儿科,四川成都610041

出　　处：《四川医学》2015年第8期1069-1072,共4页Sichuan Medical Journal

摘　　要：目的 了解散发性、急性婴幼儿Hu NVs性肠炎临床特征和流行病学资料。方法 采用横断面调查的研究方法,收集我院门、急诊就诊和住院婴幼儿中急性非细菌性肠炎的大便标本,通过问卷调查采集临床、流行病学资料。检测A组轮状病毒抗原,阴性者纳入研究;对纳入标本提取病毒RNA,RT-PCR方法检测Hu NVs。分析检出率、发病年龄、发病时间、主要临床表现。结果 婴幼儿急性非细菌性肠炎并且A组轮状病毒抗原检测为阴性的病例149份,RT-PCR方法检测有46例扩增出Hu NVs条带,检出率30.9%。Hu NVs感染患儿年龄（13.59±9.66）个月;发病时间集中在每年9～11月份,临床表现主要包括腹泻、呕吐、发热、不同程度脱水。结论 Hu NVs仅次于轮状病毒,是引起散发性、急性婴幼儿肠炎的第二位的病毒。Objective The aim of the present study was to describe the epidemiologic and clinical characteristics of hu- man noroviruses among children with symptoms of acute nonbacterial gastroenteritis. Methods Stool samples and clinical data were collected between June 2005 and December 2006 from sporadic symptomatic children. All of the specimens were detected by RT-PCR. Results With 46 HuNVs infections were identified in the 149 specimens, the prevalence of human nomviruses causing sporadic cases of acute gastroenteritis in young children was 30. 9%. The average age of children infected HuNVs was 13.59 ± 9.66 months. And the epidemic period of HuNVs was September-December. Conclusion Besides rotavirus, HuNVs were the second common causative viral agent in acute sporadic gastroenteritis of infant and children.

关 键 词：婴幼儿 急性肠炎 诺如病毒 临床特征 

分 类 号：R725.1[医药卫生—儿科]