氯己定口腔护理预防呼吸机相关性肺炎中文文献的Meta分析  

Oral Care with Chlorhexidine in Preventing Ventilator Associated Pneumonia among Chinese Patients: A Meta-analysis

作　　者：杨志兰[1] 柴建华[1] 舒红文[1] 周建芳[1] 彭文涛[2] 

机构地区：[1]崇州市人民医院,四川崇州611230 [2]四川大学华西第二医院,四川成都610041

出　　处：《四川医学》2015年第8期1119-1121,共3页Sichuan Medical Journal

摘　　要：目的系统评价国内使用氯己定口腔护理预防呼吸机相关性肺炎的有效性。方法计算机联机检索CNKI、VIP、万方数据库(各数据库检索时间为创建至2014年12月)中关于使用氯己定口腔护理预防呼吸机相关性肺炎的随机对照试验(RCT),用Rev Man5.3软件对数据进行Meta分析。结果共纳入15篇RCT,包括1909例患者。Meta分析结果显示:使用氯己定口腔护理预防呼吸机相关性肺炎的效果优于对照组[RR=0.45,95%CI(0.38,0.54),P<0.01]。结论基于现有临床证据,使用氯己定口腔护理预防呼吸机相关性肺炎的有效性较高。但由于纳入研究质量较差,本结论尚需要更高质量临床RCT予以证实。Objective To systematically evaluate the efficacy and safety of oral care with chlorhexidine in preventing ventilator associated pneumonia in Chinese patients. Methods Studies were identified through CNKI, VIP and WANFANG Data- bases. Eligible studies were randomized controlled trials （RCT）of oral care with chlorhexidine in preventing ventilator associated pneumonia among Chinese patients. Meta analysis was carried out by RevMan 5.3 software. Results 15 RCTs were included （1909 patients）. The Meta analyses showed that oral care with chlorhexidine in preventing ventilator associated pneumonia were superior to those of the control group [ RR = 0. 45,95 % CI （0. 38,0. 54）, P 〈 0. 01 ]. Conclusion The present meta-analysis in- dicates a beneficial effect of oral care with chlorhexidine in preventing ventilator associated pneumonia. However, further studies with rigorous design and large sample size are needed in the future because of study heteogeneity.

关 键 词：氯己定 口腔护理 呼吸机相关性肺炎 META分析 

分 类 号：R473[医药卫生—护理学]