环磷酰胺联合激素治疗成人复发性微小病变肾病综合征疗效观察  

Effect of Cyclophosphamide Combined with Steroids in Treatment of Adult Recurrent Small Nephrotic Syndrome

作　　者：袁锦[1] 朱再志 许志忠[1] 蒲超[1] 白佳柠 陈永忠[1] 

机构地区：[1]眉山市人民医院肾内科,四川眉山620010

出　　处：《四川医学》2015年第8期1138-1140,共3页Sichuan Medical Journal

摘　　要：目的观察环磷酰胺联合激素治疗复发性微小病变肾病综合征的远期临床疗效。方法选取2009年12月至2012年7月我院收治的成人复发性微小病变性肾病综合征患者81例,随机分为两组,其中对照组40例,接受常规泼尼松治疗;观察组41例,行环磷酰胺联合泼尼松治疗。随访2年,比较两组患者远期临床疗效。结果对照组完全缓解18例,部分缓解14例,无效8例,发生不良反应15例,复发12例。观察组完全缓解32例,部分缓解7例,无效2例,发生不良反应6例,复发4例。两组患者临床缓解率、不良反应发生率及短期复发率差异有统计学意义(P<0.05)。结论环磷酰胺联合激素治疗复发性微小病变肾病综合征临床疗效好,不良反应及短期再复发率低。Objective To observe the clinical effect of cyclophosphamide combined with prednisone in recurrent minimal change disease （MCD） in Meishan area. Methods Of 41 cases with MCD in adult from December 2009 to July 2012,40 cases were treated only with prednisone as control group. Following up two years, we compared thd long-term outcome between the two groups,and 41 cases with cyclophosphamide combined with prednisone as observing group. Followiny up two years, we compared the long-term outcome between the two groups. Results In observing group,32 cases were complete remission,7 cases were par- tially remission, 2 cases were invalid, adverse reactions 15 cases. 4 cases had relapsed one year after drug withdrawal. In control group, 18 cases were complete remission, 14 cases were partially remission, 8 cases were invalid, adverse reactions 6 cases. 12 ca- ses had relapsed in one year. The difference about clinical remission rate,adverse reaction and recurrence rate in a short time had statistical significance（P 〈 0.05）. Conclusion Applying cyclophosphamide combined with prednisone in MCD have valid effect and lower adverse reaction and recurrence rate.

关 键 词：微小病变型肾病综合征 复发 环磷酰胺 

分 类 号：R692.3[医药卫生—泌尿科学]