高压氧联合纳洛酮抢救急性中毒性昏迷临床疗效观察及安全性评价  

Evaluation on observation and safety of hyperbaric oxygen combined with naloxone in the treatment of acute toxic coma

作　　者：岑斌[1] 

机构地区：[1]简阳市人民医院重症监护室,四川简阳641400

出　　处：《中国医学前沿杂志（电子版）》2015年第6期122-124,共3页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的：探讨高压氧联合纳洛酮抢救急性中毒性昏迷的临床疗效及安全性。方法选取2006年3月至2014年3月于本院接受诊治的急性中毒性昏迷患者109例为研究对象，根据随机数表法将其分为观察组（56例）和对照组（53例）。观察组患者采用高压氧联合纳洛酮治疗，对照组患者仅给予纳洛酮治疗。比较两组患者治疗后昏迷至清醒时间、治疗总有效率及平均住院时间。结果观察组治疗后昏迷至清醒时间＜6小时患者显著多于对照组，＞24小时患者显著少于对照组（P＜0.05）；两组患者昏迷至清醒时间在6～12小时、12～24小时所占比例比较差异无显著性（P＞0.05）。观察组患者治疗总有效率为98.21%（55/56），对照组为84.91%（45/53），两组比较差异具有显著性（P＜0.05）。观察组患者平均住院时间显著短于对照组（P＜0.05）。结论高压氧联合纳洛酮抢救急性中毒性昏迷临床疗效显著，可明显加快患者清醒时间，缩短住院时间，安全可靠，值得临床推广应用。ObjectiveTo explore the clinical efficacy and safety of hyperbaric oxygen combined with naloxone for rescuing acute toxic coma.Method109 cases of acute toxic coma in our hospital from March 2006 to March 2014 were selected as the research objects, and according to the random table number were divided into observation group （n=56） and control group （n=53）. Observation group were given hyperbaric oxygen combined with naloxone treatment, control group were given naloxone. Compared two groups of time of acoma, total effective rate and average hospitalization time.ResultObservation group after treatment of coma to waking time〈6 hours was signiifcantly higher than control group, and〉24 hours of patients was signiifcantly lower than control group （P〈0.05）; and the two groups of patients with coma to waking time proportion of 6~12 hours, 12~24 hours had no signiifcant difference （P〉0.05）. The total effective rate of the observation group was 98.21% （55/56）, control group was 84.91% （45/53）, the difference between the two groups was signiifcant （P〈0.05）. The average hospitalization time of the observation group was signiifcantly shorter than control group （P〈0.05）.ConclusionThe clinical effect of hyperbaric oxygen combined with naloxone in the treatment of acute toxic coma is signiifcant, it can signiifcantly accelerate awake time, shorten the hospitalization time, it is safe and reliable, worthy of clinical application.

关 键 词：高压氧 纳洛酮 急性中毒 昏迷 

分 类 号：R595.4[医药卫生—内科学]