前列地尔联合托拉塞米治疗顽固性心力衰竭的临床效果分析  

Analysis of clinical effect of alprostadil combined with torasemide in the treatment of refractory heart failure

作　　者：徐时平[1] 朱琳莲 潘小进[1] 姚成俊[1] 

机构地区：[1]江苏省东台市人民医院心血管内科,江苏东台224200

出　　处：《中国当代医药》2015年第24期88-90,共3页China Modern Medicine

摘　　要：目的 探讨前列地尔联合托拉塞米治疗顽固性心力衰竭患者的临床效果。方法 选取2012年1月~2014年1月本院收治的48例顽固性心力衰竭患者,将其随机均匀分为对照组、观察组,每组24例。对照组给予ACEI、硝酸甘油、洋地黄等常规治疗,观察组在对照组基础上给予前列地尔联合托拉塞米治疗,比较两组的相关超生指标[左心室舒张内径（LVEDD）、左室射血分数（LVEF）、心脏指数（CI）、每搏输出量（SV）、E/A值]、临床效果、不良发应发生情况。结果 观察组治疗后的相关超声指标[左室射血分数（LVEF）、心脏指数（CI）、每搏输出量（SV）]均较对照组明显改善（P〈0.05）;观察组的总有效率明显高于对照组,不良反应发生率明显低于对照组（P〈0.05）。结论 前列地尔联合托拉塞米治疗顽固性心力衰竭的临床效果较好,安全性高。objective To explore the clinical effect of alprostadil combined with torasemide in the treatment of refractory heart failure. Methods From January 2012 to January 2012,48 patients with refractory heart failure treated in our hospital were selected and divided into control group（n=24） and observation group（n=24）.Control group was given routine treatment such as ACEI,nitroglycerin,digitalis and so on,while observation group was given alprostadil combined with torasemide on the basis of control group.Related ultrasound indexes [left ventricular diastolic diameter（LVEDD）,left ventricular ejection fraction（LVEF）,cardiac index（CI）,stroke volume（SV） and E/A value],clinical effect and incidence of adverse reaction between two groups was compared respectively. Results Related ultrasound indexes（LVEF,CI,SV） after treatment were obviously improved in observation group compared with control group（P〈0.05）;the total effective rate in observation group was obviously higher than that of control group,the incidence rate of adverse reaction was obviously lower than that of control group（P〈0.05）. Conclusion The clinical effect of alprostadil combined with torasemide in the treatment of refractory heart failure is better and has higher safety.

关 键 词：顽固性心力衰竭 前列地尔 托拉塞米 

分 类 号：R541.6[医药卫生—心血管疾病]