IL-6、IL-8及IL-10在肺炎支原体肺炎患儿血清中的表达及临床意义  

Expression of IL-6,IL-8 and IL-10 in serum of children with mycoplasma pneumonia and its significance

作　　者：刘芳[1] 赵宇华[1] 陈霜慧 

机构地区：[1]同济大学附属东方医院儿科,上海200120

出　　处：《实用临床医药杂志》2015年第17期61-63,66,共4页Journal of Clinical Medicine in Practice

基　　金：上海市科学技术委员会医学引导类项目(13401907200);中国高校医学期刊临床专项资金项目(11523058)

摘　　要：目的探讨白细胞介素(IL)-6、IL-8及IL-10在肺炎支原体肺炎(MPP)患儿血清中的表达及临床意义。方法选取MPP患儿143例为观察组,其中急性期71例,恢复期72例;急性期患者按病情严重程度分为重症组30例和轻症组41例,另设同期健康体检儿童70例为对照组,检测各组受试者静脉血血清IL-6、IL-8和IL-10的水平。结果观察组急性期和恢复期患儿血清IL-6、IL-8水平均高于对照组,IL-10水平低于对照组,差异均有统计学意义(P<0.01)。其中急性期患儿血清IL-6、IL-8水平均高于恢复期,IL-10水平低于恢复期,差异均有统计学意义(P<0.01)。急性期重症组患儿血清IL-6、IL-8水平均高于轻症组,IL-10水平低于轻症组,差异均有统计学意义(P<0.01)。结论 IL-6、IL-8及IL-10参与MPP患者的免疫调节过程,可能与MPP的严重程度和转归相关。Objective To explore the expression of interleukin （IL）-6, IL-8 and IL-10 in the serum of children with mycoplasma pneumonia （MPP） and its significance. Methods A total of 143 MPP children were selected as observation group, in which 71 were in acute stage and 72 in convalescent stage. Children in acute stage were re-divided into severe group （30 cases） and mild group （41 cases）. Meanwhile, another 70 healthy children undergoing physical examination served as control group. Serum IL-6, IL-8 and IL-10 levels in venous blood of all groups were detected. Results Children in both acute and convalescent stages of observation group were evidently higher than control group in serumLevels of IL-6 and IL-8, but apparently lower in IL-10 level, and the differences were significant （P〈 0.01）. In addition, children in acute stage were markedly higher in serum IL-6 and IL-8 levels but obviously lower in IL-10 level than those in convalescent stage, and there were significant differences （P 〈 0.01 ）. Of children in acute stage, severe group was no- tably higher in serum IL-6 and IL-8 levels but prominently lower in IL-10 level than mild group, and the differences were significant （P 〈 0.01）. Conclusion IL-6, IL-8 and IL-10 all participate in the immune-regulative process of MPP, which is in potential association with the severity and outcome of MPP.

关 键 词：肺炎支原体 呼吸道感染 白细胞介素 

分 类 号：R563.1[医药卫生—呼吸系统]