妇炎栓抗炎、镇痛与刺激性研究  

Study on the Anti-inflammatory,Antalgic Effects and Irritation of Fuyan Suppository

作　　者：吴文波 孙丽琛 刘兴 

机构地区：[1]临沂市肿瘤医院,山东临沂276001

出　　处：《中国药房》2015年第25期3504-3506,共3页China Pharmacy

摘　　要：目的：研究妇炎栓抗炎、镇痛、刺激性。方法：以小鼠耳肿胀实验（妇炎栓剂量为4.5、3.0、1.5 g/kg）、小鼠足跖肿胀实验（测定时间点为5 min与0.5、1、4、6 h）研究妇炎栓的抗炎作用;以小鼠扭体反应实验（妇炎栓剂量为4.5、3.0、1.5 g/kg）研究妇炎栓止痛作用;以家兔阴道黏膜刺激实验研究妇炎栓的阴道刺激性（妇炎栓剂量为1.0 g/只,每天1次,连续1周）。结果：4.5、3.0、1.5 g/kg剂量下,妇炎栓可抑制小鼠的耳肿胀、减少小鼠扭体反应次数;3.0 g/kg剂量下,给药0.5-6 h时妇炎栓可抑制小鼠足跖肿胀;对家兔阴道无刺激性。结论：妇炎栓具有较好的抗炎和止痛作用;对家兔阴道无刺激性,理论上可认为阴道给予妇炎栓较安全。OBJECTIVE：To study the anti-inflammatory,antalgic effects and irritation of Fuyan suppository. METHODS：Mouse auricle swelling test（Fuyan suppository 4.5,3.0 and 1.5 g/kg for administration）and mouse vola pedis swelling test（5 min and 0.5,1,4,6 h）were employed to study the anti-inflammatory effect of Fuyan suppository. Mouse writhing response test（Fuyan suppository 4.5,3.0 and 1.5 g/kg） was used to study the antalgic effect. Rabbit vagina mucosa irritation test was adopted to study the vaginal irritation（Fuyan suppository 1.0 g/rabbit,once daily for one week）. RESULTS：Fuyan suppository at a dose of4.5,3.0 or 1.5 g/kg could inhibit auricle swelling of mice and reduce the times of mice＇s writhing response. 3.0 g/kg Fuyan suppository could,at 0.5-6 h from administration,inhibit vola pedis swelling of mice and be nonirritating to the rabbit＇s vagina. CONCLUSIONS：Fuyan suppository has better anti-inflammatory and antalgic effects and is nonirritating to the rabbit＇s vagina. Theoretically,vaginal administration of Fuyan suppository can be considered as safe.

关 键 词：妇炎栓 药效学 小鼠 家兔 

分 类 号：R285[医药卫生—中药学]