孤儿G蛋白偶联受体55的研究进展  

Research progress on orphan receptor GPR55

作　　者：王紫媛[1,2] 丁剑午[2] 

机构地区：[1]南昌大学医学部,南昌330006 [2]南昌大学第二附属医院肿瘤科,南昌330006

出　　处：《生命的化学》2015年第4期509-514,共6页Chemistry of Life

摘　　要：孤儿GPR55是新发现的G蛋白偶联受体,主要分布在大脑、肾上腺、胃肠道、脾脏、内皮细胞、破骨细胞等全身各个区域,参与调节体内一系列生理、病理活动,包括中枢神经系统动作协调、神经或炎性疼痛、骨生理、胃肠道炎症、肥胖、2型糖尿病以及癌症等。深入研究GPR55的生物学功能及其分子机制有助于揭示GPR55相关疾病的发病机制,从而为GPR55作为新的靶向治疗靶点提供理论依据。Orphan receptor GPR55 is a newly discovered G protein-coupled receptor, mainly distributed in the brain, adrenal glands, gastrointestinal tract, spleen, endothelial cells and osteoclasts. GPR55 is found par- ticipating in the regulating a series of physiological and pathological activities, such as central nervous system coordination, nerve and inflammatory pains, bone physiology, gastrointestinal inflammation, obesity, diabetes as well as cancer. The further research of GPR55＇s biological functions and its molecular mechanism can be considered helpful for finding a series related pathogenesis, which improves the theoretical basis making GPR55 as the new target in targeted therapy.

关 键 词：孤儿G蛋白偶联受体55 癌症 溶血磷酯酰肌醇 大麻素受体 

分 类 号：R3411[医药卫生—基础医学]