低氧应激在细胞和分子水平的研究进展  

Progress in research on hypoxia stress at cell and molecular levels

作　　者：孔凡志[1] 沈欢欢[1] 彭梦玲 杨焕民[1] 

机构地区：[1]黑龙江八一农垦大学动物科技学院,黑龙江大庆163319

出　　处：《中国生物制品学杂志》2015年第8期871-874,879,共5页Chinese Journal of Biologicals

基　　金：黑龙江省教育厅海外学人科研资助项目(1253HQ013)资助课题;黑龙江八一农垦大学学成;引进人才科研启动计划资助课题(1253HQ013)

摘　　要：应激是机体受到体内外非特异性有害因子的刺激表现出的机能障碍和防御反应。应激反应是生命体为了生存和发展所必需的机体防护机制的重要组成部分,当机体处于低氧状态下时,细胞作为机体的基本结构单元,会首先产生应激反应,而这种反应会因为细胞类型以及应激原刺激强度和时间的不同而不同。本文主要从细胞和分子水平阐述了低氧对细胞活力、增殖、凋亡以及某些基因表达调控的影响。Stress is the manifestation of dysfunction and defense reaction when organisms are stimulated by in vivo and in vitro nonspecific harmful factors. Stress response is an important part of essential organism protective mechanism for living and development. When organisms are under hypoxia stress, cells, as a basic structure unit of organisms, will generate stress response firstly. However, the hypoxia stress response is dependent on the cell types, stimulus intensity and time for stimulation. This paper reviews the influence of hypoxia on cell vitality, proliferation, apoptosis, and regulation of expression of a certain genes at cell and molecular levels.

关 键 词：低氧 应激反应 细胞水平 分子水平 

分 类 号：Q26[生物学—细胞生物学]