140例儿童人苍白杆菌败血症临床分布及耐药性分析  

Clinical Distribution and Antibiotic Resistance of Ochrobactrum Anthropi in 140 Cases of Septicemia Children

作　　者：胡建芬[1] 隆彩霞[1] 张林[1] 

机构地区：[1]湖南省儿童医院,湖南长沙410007

出　　处：《儿科药学杂志》2015年第9期35-37,共3页Journal of Pediatric Pharmacy

摘　　要：目的:调查儿童人苍白杆菌败血症的临床分布及耐药性,为临床抗菌药物的使用及感染控制提供依据。方法:对我院2013年1月至2014年10月败血症住院患儿血液培养分离出的140株人苍白杆菌的临床分布及其对12种抗菌药物的耐药情况进行回顾性分析。结果:分离出人苍白杆菌的140例败血症患儿年龄以29 d^5岁为主(83.6%),主要集中在重症监护科(30.7%)、呼吸内科(22.1%)、心血管内科(17.9%);患儿多伴有呼吸道症状(80.7%)及发热(68.6%)。人苍白杆菌对哌拉西林、哌拉西林/他唑巴坦、氨曲南、头孢唑林、氨苄西林/舒巴坦、头孢噻肟耐药率较高,达90%以上,对头孢吡肟、厄它培南、亚胺培南、庆大霉素、环丙沙星、美罗培南敏感性较好,耐药率分别为9.3%、9.3%、3.6%、0.7%、0.7%、0。结论:人苍白杆菌可致儿童败血症,其耐药率较高;治疗可选用头孢吡肟、亚胺培南或美罗培南等敏感性较高的药物。Objective： To investigate the clinical distribution and antibiotic resistance of Ochrobactrum anthropi in septicemia children, so as to provide the basis for the use of antibiotics and infection control. Methods： Retrospective analysis the clinical distribution of 140 strains Ochrobactrum anthropi and antibiotic resistance to 12 antibiotics isolated in our hospital were collected between January 2013 and October 2014. Results： One hundred and forty strains of Ochrobactrum anthropi were isolated from children diagnosed of septemia, the majority of children were aged between 29 days to 5 years （ 83.6% ）, mainly hospitalized in the department of the intensive care unit （30.7%）, department of respiratory medicine （ 22. 1% ）, and the department of vasculocardiology （ 17. 9% ）, et al. Mainly accompanied with symptoms of respiratory tract （80.7%） and fever （68.6%）. The drug resistance rates to piperacillin, piperacillin/ tazobactam, aztreonam, cephazolin, ampicillin/sulbactam and cefotaxime were very high, up to 90%, while the Ochrobactrum anthrop expressed a high sensitivity to cefepime, ertapenem, imipenem, gentamicin, ciprofloxacin and meropenem, the drug resistance rates were 9.3%, 9.3%, 3.6%, 0. 7%, 0.7%, 0, respectively. Conclusion： Ochrobactrum anthropi has play a role in children patients with septemia, with a high rate of drug resistance, the most effective antimicrobial agents for treating were cefepime, imipenem or meropenem.

关 键 词：人苍白杆菌 败血症 耐药性 儿童 

分 类 号：R725.6[医药卫生—儿科]