骨髓间充质干细胞在治疗股骨头坏死方面的临床研究  

Clinical study on the treatment of femoral head necrosis with Bone marrow mesenchymal stem cells

作　　者：于德军[1] 刘丽晶[2] 吕艳欣[3] 田少华[1] 

机构地区：[1]齐齐哈尔医学院附属第三医院骨二科 [2]齐齐哈尔医学院附属第三医院妇二科 [3]齐齐哈尔医学院生物遗传教研室

出　　处：《齐齐哈尔医学院学报》2015年第21期3126-3127,共2页Journal of Qiqihar Medical University

摘　　要：目的探讨骨髓间充质干细胞移植技术在治疗股骨头坏死的疗效。方法选用齐齐哈尔医学院附属第三医院骨科股骨头坏死患者60例,按ARCO分期均为1~2期,其中采用死骨刮除＋植骨＋骨髓间质干细胞移植技术治疗股骨头坏死患者30例,采用传统死骨刮除＋植骨治疗股骨头坏死患者30例,通过放射线检查术后骨质变化情况和VAS疼痛评分及Harris髋关节功能评分进行对比,对两种治疗方法疗效优良率采用χ2检验。结果两组患者住院时间及治疗效果比较差异显著,有统计学意义。结论骨髓间充质干细胞移植治疗股骨头坏死,能够有效恢复髋关节功能,减轻髋关节疼痛症状,改善股骨头坏死区域的血运,防止股骨头塌陷,保护股骨头,延缓髋关节置换的手术时间。Objective To study the curative effect of bone marrow stem cell transplantation in the treatment of the femoral head necrosis. Methods Selecting 60 cases of patients in orthopedic department in the third hospital affiliated to Qiqihar medical college as study subjects,all the patients were at 1 or 2 stage according to ARCO stage standard. Among the patients 30 cases received the treatment of dead bone curettage plus bone transplantation plus marrow mesenchymal stem cell transplantation technology,however,the other 30 cases adopted the traditional treatment including dead bone curettage and bone transplantation. The change of the bone and the postoperative VAS pain score and Harris hip score were compared between the two groups,the rate of good curative effect of two kinds of treatment method using χ2test. Results The differences of hospitalized time and cure efficacy between the two groups were statistically significant. Conclusions Treating femoral head necrosis with bone marrow mesenchymal stem cell transplantation can effectively restore the hip joint function,reduce hip pain symptoms,improve the blood supply of femoral head necrosis area,preventing the collapse of the femoral head,achieve femoral head protection and delay the time of hip replacement surgery.

关 键 词：骨髓间充质干细胞 股骨头坏死 临床研究 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]