藏药牙膏配方工艺与抗炎作用研究  

Study on Tibetan Medicine Toothpaste Formula Technology and Its Anti-Inflammatory Effect

作　　者：许凉凉 伊辛[1] 尹雪雁 魏文浩[1] 蔡程科[2] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]北京中医药大学研究生院,北京100029

出　　处：《世界中医药》2015年第7期1074-1077,共4页World Chinese Medicine

基　　金：北京中医药大学自主课题藏医药类(编号:2013-ZYY-01);北京中医药大学复方中药制药研究创新团队项目资助(编号:2011-CXTD-13)

摘　　要：目的:研究确定藏药牙膏最佳配方并进行抗炎药效研究。方法:以藏药诃子、白矾、寒水石等为添加功效成分,考察不同配比的甘油、二氧化硅、非离子瓜尔胶对牙膏感官性状的影响,并采用二甲苯致小鼠耳肿胀模型,考察研究制备的藏药牙膏的抗炎药效作用,计算肿胀度和抑制率,分析藏药牙膏对炎症的抑制作用。结果:最佳配方为藏药3.3 g、甘油25g、70%山梨醇40 g、二氧化硅22 g、非离子瓜尔胶0.7 g、薄荷油1.1 g、十二烷基硫酸钠(K12)2.2 g、尼泊金乙酯0.1 g、尼泊金丙酯0.05 g、糖精0.35 g、水适量。藏药牙膏组对二甲苯致小鼠耳肿胀有显著的抑制作用(P<0.01),且与云南白药牙膏对比,藏药牙膏的抗炎作用优于云南白药牙膏组。结论:制备所得的藏药牙膏膏体细腻光亮,呈半透明深棕绿色,气味清凉,黏稠度适中,且具有良好的抗炎效果,具有广阔的市场前景。Objective： To investigate and determine the best formula of Tibetan medicine toothpaste and study the anti-inflammato- ry effects. Methods： Tibetan medicine were added as functional component. The effects of toothpaste forming process was measured by sensory property to evaluate the different ratio of glycerol, Silicon dioxide and non-ionic guar gum. Ear swelling was induced by dimethylbenzene in mice. Tibetan medicine toothpate was daubed on the ears of mice, then, the ear swelling volume was measured to analyze the anti-inflammatory effects of Tibetan medicine toothpaste. Results： The best formula was made of 3.3 g of Tibetan medi- cine,25 g of glycerin,40 g of sorbitol with the 70% concertration,22 g of Silicon dioxide,0.7g of non-ionlc guar gum, l. 1 g of oleummenthae,2.2 g of sodium dodecyl sulfate （K12） ,0.1 g of ethylparaben,0. 05 g of propylparaben,0.35 g of saccharinand as well as proper weight of water. The Tibetan medicine toothpaste markedly suppressed the ear swelling induced by dimethylbenzene, and in contrast to Yunnan Baiyao toothpaste, the anti-inflammatory effects of Tibetan medicine toothpaste was better. Conclusion： The Tibetan medicine toothpaste is smooth and bright having a gentle mint taste, and its color is translucence dark brown and the viscosity is moderate. The Tibetan medicine toothpaste has good anti-inflammatory effect.

关 键 词：藏药牙膏 配方 抗炎 耳肿胀法 

分 类 号：R29[医药卫生—民族医学] R-332[医药卫生—中医学]