相同品质中药的系统理论判别方法  

A Systematically Theoretical Distinguish Approach for Traditional Chinese Medicine with Identical Quality

作　　者：邹华彬[1] 

机构地区：[1]山东大学化学与化工学院,济南250100

出　　处：《世界中医药》2015年第7期1078-1082,共5页World Chinese Medicine

基　　金：山东省中医药科技发展计划项目(编号:2013-157)

摘　　要：目的:提出了中药个体品质及群体品质鉴别的概念。建立了相同品质中药群体的系统理论判别方法。方法:根据描述生物体系遗传与变异信息的双指标信息理论方程,建立生物体系个体同品质的定量标准,由此构建每个样品的初级同品质特征序列。构建了中药群体同品质优化判别方法:群体特征序列最大有效样本数法,变化Pg=x^100%,58%≤x≤64%,在整体上优化每个样品的同品质特征序列,使群体样本的核心特征序列中的总样本数与关联序列中的总样本数差值Y=ΣMi=1(Nci-Nri)最大,实现中药群体同品质的优化判别。该理论系统基于生物系统内禀性质,可以实现相同品质中药群体的严格理论判别。结果:3种组成非常相似的中药复方红外指纹图谱的分析结果很好地证明了该理论预测。结论:该研究提供了一种判别相同品质中药的可行理论方法。Objective： To propose an idea of quality identification of individual Chinese medicinal and the concept of quality identi- fication of traditional Chinese medicinal population, and to establish a system of theoretical distinguishing approach for population traditional Chinese medicinals with identical quality. Methods：According to dual index information theory equation I = - （PglnPg ＋PalnPoa, which can describe the biological inheritance and variation information, an absolutely and accurately quantitative standard Pg ≥61% was deduced. It was qualified to be the theoretical criterion for individual traditional Chinese medicinal with i- dentical quality. Relying on the standard, each sample＇s characteristic sequence could be set up. Moreover, in reference to the randomness, the fluctuation and the asymmetry of biological properties, the optimum distinguish method for traditional Chinese medicine population with identical quality was built up too, which was named the maximum efficient sample number method of pop- ulation characteristic sequences. In this method, to vary the x ≤ P≤ 100%, 58% ≤ x ≤ 64%, and to optimize all samples＇ characteristic sequence in order to make the difference of total sample number, involved in the core characteristic sequences of all samples, between the total sample number, in relative sequences of all samples, that is Y = （ Nci-Na ）, to be the largest. In this way the quality of traditional Chinese medicine was discriminated optimally. This systematical theory is able to perform strict theo- retical identification of traditional Chinese medicine population with identical quality as well as individual medicinal quality. Re- stilts ： This approach, or theoretical prediction was perfectly proved by the analysis of infrared fingerprint spectra of three species of traditional Chinese medicinals with very similar composition. Conclusion：This research provides us with a qualified theoretical method for recognizing identical Chinese medicinals quality.

关 键 词：中药群体 相同品质 鉴别理论 生物信息理论 指纹图谱 模式识别 

分 类 号：R286.0[医药卫生—中药学]