含聚合单体微胶囊的牙科新型自修复抗菌复合树脂合成初探  

Development of novel self-healing and antibacterial resin composite containing microcapsules filled with polymerizable healing monomer

作　　者：吴峻岭[1] 张强[2] 朱婷[1] 葛建华[3] 周传健[3] 

机构地区：[1]山东大学口腔医学院口腔修复科·山东省口腔生物医学重点实验室,济南250012 [2] 济南市口腔医院口腔种植诊疗中心 [3] 山东大学材料科学与工程学院高分子材料研究所

出　　处：《中华口腔医学杂志》2015年第8期469-473,共5页Chinese Journal of Stomatology

基　　金：基金项目：山东省自然科学基金（zR2014HM073）

摘　　要：目的合成含聚合单体微胶囊的牙科新型自修复抗菌复合树脂，并探讨相关性能，为其进一步临床应用提供参考。方法制备含聚合单体三乙二醇二甲基丙烯酸酯的微胶囊，分别以0、2．5％、5．0％、7．5％及10．O％质量分数添加至含长链烷基季铵盐新型纳米二氧化硅抗菌填料的复合树脂中，生成含聚合单体微胶囊的牙科新型自修复抗菌复合树脂（新型树脂组），以纳米瓷化复合树脂（TetricN．Cemm）为对照。三点弯曲实验检测各组树脂弯曲强度和弹性模量（每组样本量为6）；单刃v形切口梁法测试各组树脂断裂韧性及自修复效率（每组样本量为6），同时进行扫描电镜观察。结果引入7．5％聚合单体微胶囊时，新型树脂组弯曲强度和弹性模量分别为（96．4±14．3）MPa和（6．2±1．1）GPa，与对照组[分别为（99．1±11．9）MPa和（6．1±1．1）GPa]差异均无统计学意义（P〉0．05）；当聚合单体微胶囊质量分数为7．5％和10．0％时，新型树脂的自修复效率分别为（66．8±7．0）％和（79.3±9．7）％；扫描电镜示愈合面有黑色不规则薄膜覆盖。结论含聚合单体微胶囊的牙科新型自修复抗菌复合树脂具有较强的自修复功能，展示了良好的临床应用前景。Objective To develop novel self-healing and antibacterial resin composite containing microcapsules filled with polymerizable healing monomer,and to measure its properties for further clinical application.Methods Microcapsules filled with healing monomer of triethylene glycol dimethacrylate were synthesized according to methods introduced in the previous research.Microcapsules were added into novel resin composite containing nano-antibacterial silica fillers grafted with long chain alkyl quaternary ammonium at mass fractions of 0,2.5%,5.0%,7.5% or 10.0%.A commercial resin composite（Tetric N-Ceram） was used as control.Flexural test was used to measure resin composite flexural strength and elastic modulus.The single edge Ⅴ-notched beam method was used to measure fracture toughness and self-healing efficiency.Scanning electron microscope（SEM） was used to examine the fractured surface of selected specimen for investigation of fracture mechanisms.Results The flexural strength and elastic modulus of the resin composite were （96.4 ± 14.3） MPa and （6.2 ±1.1） GPa respectively after incorporation of microcapsules up to 7.5%,and no significant difference was found between the experimental group and the control group[（99.1±1 1.9） MPa and （6.1±1.1） GPa] （P〉0.05）.The self-healing efficiency of （66.8±7.0）% and （79.3±9.7）% were achieved for resin composite with microcapsule mass fractions at 7.5% and 10.0%.SEM image showed that irregular films covered the fractured surface.Conclusions This novel self-healing and antibacterial resin composite containing microcapsules filled with polymerizable healing monomer exhibited a promising self-healing ability,which enabled itself well up for combating bulk fracture and secondary caries in clinical application.

关 键 词：复合树脂类 弹性模量 微胶囊 自修复 

分 类 号：R783.1[医药卫生—口腔医学]