NT－proBNP、和肽素评估急性冠状动脉综合征病情程度的效果  

Study the levels of NT-proBNP、Cop eptin in ACS patients and their relationships with extent of acute coronary syndrome

作　　者：王红艳[1] 张艳霞[1] 

机构地区：[1]河南省济源市人民医院心内科,河南济源450019

出　　处：《中国伤残医学》2015年第18期17-19,共3页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的：探究血浆N－末端B型脑钠肽（ N－terminal pro－B－type natriuretic peptide，NT－proBNP）、和肽素（ Copeptin）在急性冠状动脉综合征（ acutecoronary syndromes，ACS）不同类型患者中的变化，并探讨与冠状动脉病情严重程度的关系。方法：选取住院并进行冠状动脉造影的ACS患者125例，依照临床诊断标准将ACS患者分为2组，再根据Gensini积分分组进行比对。设冠状动脉正常对照组。所有入选患者于入院当天抽血检测NT－proBNP、Copeptin。结果：（1） ACS 患者两分组NT－proBNP、Copeptin浓度均高于正常对照组，并具有统计学意义（P＜0．05）；（2）NT－proBNP、Copeptin在ACS患者不同冠状动脉病变程度组间具有统计学意义（ P ＜0．05）。结论：ACS患者的NT－proBNP Copeptin显著高于正常对照组，并且与冠状动脉病变的轻重程度有关；NT－proBNP、Copeptin可作为临床上评价ACS患者病情危险程度实效性的指标。Objective：To explore the diversity of levels of N-terminal pro-B-type natriuretic peptide（ NT-proBNP）、Copeptin in patients with acute coronary syndrome（ ACS） , and to assess their clinical value.Methods：A total of 125 patients of ACS admitted were divided into three clinical types.These patients were also evaluated by Gensini score for a decision of coronary angiography（ CAG） after admission, and divided into three sub-groups.normal volunteers were designated as control groups.The venous blood samples were taken from the patients immediately after admission for detection of NT-proBNP,Copeptin.Results：①Significant differences in NT-proBNP、Copeptin were found between ACS group including the different clinical subgroups and normal group （P〈0.05）.②Significant differences in NTproBNP、Copeptin were found among two ACS sub-groups which were divided according to the severity of in patients with coronary artery disease （P〈0.05）.Conclusion：There was a correlation between levels of NT-proBNP、Copeptin and different ex-tent of coronary artery lesions in ACS patients.Combined detection of NT-proBNP、Copeptin can be helpful and effective for risk stratifi-cation of the hospitalized patients with ACS after admission.

关 键 词：急性冠脉综合征 N-末端脑利钠肽前体 和肽素 

分 类 号：R543[医药卫生—心血管疾病]