Achievements, challenges and prospects for the development of broadly protective multivalent vaccines and therapeutic antibodies against hand, foot and mouth disease  

作　　者：Ke Lyu Rong Chen 

机构地区：[1]Key Laboratory of Molecular Virology and Immunology,Institut Pasteur of Shanghai, Chinese Academy of Sciences

出　　处：《Science Bulletin》2015年第15期1305-1315,共11页科学通报（英文版）

基　　金：supported by the National Basic Research Program of China(2010CB912403);the National Natural Science Foundation of China(31370730 and 31070144)

摘　　要：Hand, foot and mouth disease(HFMD) is a significant health concern in the Asia–Pacific regions for infants and young children in recent years. However, no vaccines or therapeutics are available at present. The causative agents for HFMD include human enterovirus 71(EV71), coxsackievirus A16(CVA16) and some other viruses. Recently, tremendous progress has been made in the development of monovalent and bivalent vaccines against HFMD. A few neutralizing monoclonal antibodies against EV71 or CVA16 have been identified and characterized. Here, we reviewed some achievements for the development of broadly protective vaccines and neutralizing antibodies against HFMD, and discussed challenges and prospects toward broadly protective multivalent vaccines and therapeutic antibodies against HFMD.Hand, foot and mouth disease （HFMD） is a significant health concern in the Asia-Pacific regions for infants and young children in recent years. However, no vaccines or therapeutics are available at present. The cau- sative agents for HFMD include human enterovirus 71 （EV71）, coxsackievirus A16 （CVA16） and some other viruses. Recently, tremendous progress has been made in the development of monovalent and bivalent vaccines against HFMD. A few neutralizing monoclonal antibodies against EV71 or CVA16 have been identified and characterized. Here, we reviewed some achievements for the development of broadly protective vaccines and neutralizing antibodies against HFMD, and discussed challenges and prospects toward broadly protective multivalent vaccines and therapeutic antibodies against HFMD.

关 键 词：HAND foot and mouth disease （HFMD） Human enterovirus 71 （EV71） Coxsackievirus A 16（CVAI6） - Vaccine Neutralizing antibodies 

分 类 号：R392-33[医药卫生—免疫学]