p57、p53和p63蛋白对葡萄胎和水肿性流产的鉴别诊断价值  

Diagnostic Value of p57, p53 and p63 Proteins in Distinguishing Hydatidiform Mole from Hydropic Abortion

作　　者：韩淑珍[1] 王杜鹃[1] 曾丽华[1] 何丹[1] 陈小毅[2] 

机构地区：[1]广东医学院附属东莞市厚街医院病理科,523808 [2]广东医学院基础医学院病理教研室

出　　处：《岭南急诊医学杂志》2015年第4期327-329,共3页Lingnan Journal of Emergency Medicine

基　　金：广东省东莞市医疗卫生科技计划项目(201210515023170)

摘　　要：目的:探讨p57、p53和p63蛋白在鉴别诊断水肿性流产(HA),部分性葡萄胎(PHM)和完全性葡萄胎(CHM)的价值。方法:采用免疫组织化学染色法检测HA(n=21)、PHM(n=28)和CHM(n=32)石蜡组织切片中p57、p53和p63的表达。结果:HA、PHM和CHM组织中,p57蛋白的阳性表达率分别为90.5%(19/21)、100%(28/28)和0.0%(0/32),PHM和CHM组间有明显差异(P<0.01);p53蛋白的阳性表达率分别为28.3%(5/21)、71.4%(20/28)和87.5%(28/32),HA、PHM组相比也有明显差异(P<0.01);p63蛋白的阳性表达率分别为81.0%(17/21)、89.3%(25/28)和87.5%(28/32),各组间均无统计学差异。结论 :以常规石蜡切片的病理形态特征为基础,结合免疫组化检测p57、p53和p63的结果,对鉴别水肿性流产和葡萄胎具有重要价值。Objective：To investigate the value of p57 , p53 and p63 proteins in distinguishing diagnosis of hydropic abortion （HA）, partial hydatidiform mole （PHM） and complete hydatidiform mole （CHM）. Methods：Immunohistochemical stains （Envision method） for p57, p53 and p63 were performed in tissue samples of HA （n=21）, PHM （n=28） and CHM （n=32）. Results：The positive rates of p57 in HA, PHM and CHM were 90.5%（19/21）,100%（28/28） and 0%（0/32）, respectively. There was a significant difference between PHM and CHM （P〈0.01）. The positive rates of p53 in HA and PHM were 28.3%（5/21） and 71.4%（20/28） and 87.5%（28/32） respectively, and the difference between them was statistically significant（P＆lt;0.01）. The p63 expression in HA was less than that in HM （PHM and CHM）, and the rates were 81%（17/21） and 89.3%（25/28） and 87.5%（28/32）. The expressions were not significantly different between HA and HM. Conclusion： In pathological morphological characteristics as the basis, combined with immunohistochemical detection of p57, P53 and P63, and has important value for distinguishing hydropic abortion and hydatidiform mole.

关 键 词：葡萄胎 水肿性流产 周期素依赖激酶抑制剂p57 P53 P63 

分 类 号：R714.2[医药卫生—妇产科学] R737.33[医药卫生—临床医学]