泛发性湿疹患者外周血淋巴细胞亚群的研究  

Research of lymphocyte subpopulation in peripheral blood of generalized eczema patients

作　　者：韩莹[1] 程欣[1] 

机构地区：[1]沈阳市第七人民医院皮肤科,110003

出　　处：《中国实用医药》2015年第21期40-41,共2页China Practical Medicine

摘　　要：目的探讨泛发性湿疹患者的免疫功能变化。方法应用流式细胞仪分析检测200例泛发性湿疹患者(泛发性湿疹组)外周血中的淋巴细胞亚群,并与200例正常人(正常组)进行比较。结果与正常组相比泛发性湿疹组的CD3+T细胞降低,CD3+CD4+T细胞降低,CD3+CD8+T细胞升高,CD3-CD16+56+NK细胞降低,CD4+/CD8+降低,差异有统计学意义(P<0.05)。结论免疫功能的紊乱是泛发性湿疹患者发病的一个重要机制,在泛发性湿疹的发生、发展过程中可能起到重要的作用。Objective To investigate changes of immunologic function in generalized eczema patients. Methods Lymphocyte subpopulation in peripheral blood of 200 generalized eczema patients （generalized eczema group） were detected by flow cytometry method, and they were compared with those in 200 normal people （normal group）.Results Compared with the normal group, the generalized eczema group had decreased CD3＋ T cells, CD3＋CD4＋ T cells, CD3-CD16＋56＋ NK cells, CD4＋/CD8＋ T cells, and increased CD3＋CD8＋ T cells. The difference had statistical significance （P〈0.05）.Conclusion Immune function disorder is one of the main mechanism of generalized eczema patients, and it acts with important effect in occurrence and progress of generalized eczema.

关 键 词：泛发性湿疹 淋巴细胞亚群 流式细胞分析法 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]