探讨 BA，EMAb 及 ACA与不明原因复发性自然流产的相关性  

Discussing the Correlation between BA,EMAb, ACA and Unexplained Recurrent Spontaneous Abortion

作　　者：陈柳青[1] 连炬飞[1] 曾丽[1] 赖科峰[1] 林珠[1] 

机构地区：[1]广东省妇幼保健院检验科,广州510010

出　　处：《现代检验医学杂志》2015年第4期137-140,共4页Journal of Modern Laboratory Medicine

摘　　要：目的：探讨封闭抗体（BA），抗子宫磷脂抗体（EMAb）及抗心磷脂抗体（ACA）联合检测与不明原因复发性自然流产（UPSA）的相关性。方法选取不明原因复发性自然流产144例，偶发性自然流产166例和正常体检孕妇188例，检测其 BA，EMAb 和 ACA 并行统计学分析。结果 URSA 组分别与偶发性自然流产组及对照组相比较，BA 阴性率（74.31％，25.30％和50.53％），EMAb 阳性率（35.42％，7.23％和6.91％）和 ACA 阳性率（26.39％，5.42％和5.32％）差异均有统计学意义（χ2＝19.344～74.180，P 值均＜0.05；χ2＝37.837～42.586，P 值均＜0.05；χ2＝26.355～29.270，P 值均＜0.05）。URSA 组的 BA，EMAb 和 ACA 联合检测阳性率（84.72％）明显高于偶发性自然流产组及对照组（χ2＝35.532～93.076，P 值均＜0.05）。结论BA 的缺乏，EMAb 和 ACA 的产生与不明原因复发性自然流产存在密切的关系，联合检测对辅助诊断 URSA 及其预后判断具有重要的临床指导意义。Objective To discuss the correlation between the joint detection of BA,EMAb,ACA and unexplained recurrent spontaneous abortion（URSA）.Methods Selected 144 URSA cases,166 SA（sporadic abortion）cases,188 normal pregnant women,and detected their BA,EMAb,ACA and statistical analysis of parallelism.Results Comparing URSA group with SA group and control group respectively,there were significant statistical difference between BA negative rate （74.31%, 25.30% and 50.53%）,EMAb positive rate （35.42%,7.23% and 6.91%）and ACA positive rate （26.39%,5.42% and 5.32%）（χ2 = 19.344 ~ 74.180;P 〈 0.05;χ2 = 37.837 ~ 42.586,P 〈 0.05）,（χ2 = 26.355 ~ 29.270,P 〈 0.05）.URSA group’s BA,ACA and EMAb joint detection rate of positive （84.72%）was significantly higher than SA group and the con-trol group （χ2 =35.532~93.076,P 〈0.05）.Conclusion There was a close relationship between the lack of BA,the genera-tion of EMAb,ACA and unexplained recurrent spontaneous abortion.Joint detection has important clinical significance in auxiliary diagnosis of unexplained recurrent spontaneous abortion and prognosis judgement.

关 键 词：封闭抗体 抗子宫内膜抗体 抗心磷脂抗体 不明原因复发性自然流产 

分 类 号：R714.21[医药卫生—妇产科学] R392.11[医药卫生—临床医学]