C_(21) Steroidal Saponins from Cynanchum otophyllum  

作　　者：Yi-bin Zhao Yue-mao Shen Hong-ping He Zhi-zhi Du Quan-zhang Mu Xiao-jiang Hao 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences

出　　处：《Chinese Herbal Medicines》2015年第3期273-278,共6页中草药（英文版）

基　　金：National Natural Science Foundation of China(30572322);Natural Science Foundation of Yunnan Province(2005C0036Q)

摘　　要：Objective To study the chemical structures of saponins in the rhizome of Cynanchum otophyllum（Asclepiadaceae）, and to find new compounds. Methods The total saponins of the rhizome were separated by silica gel column chromatography. The chemical structures of obtained compounds were determined by NMR and FAB-MS spectra. Results Three C21 steroidal saponins were separated. Their structures were determined as caudatin 3- O-β-D-glucopyranosyl-（1 →4）-β- D-digitoxopyranosyl-（1 → 4）-β-D-digino- pyranosyl-（1 -4）-α-D-oleandropyranoside （1）, caudatin 3-O-β-D-oleandropyranosyl- （1→4）-α-D-oleandropyranosyl-（1→4）-α-D-oleandropyranoside （2）, and caudatin 3-O- β-D-glucopyranosyl-（1 →4）-α-D-oleandropyranosyl-（1 -4）-β-D-diginopyranosyl-（1→4）- α-D-oleandropyranoside （3）, respectively. Conclusion Saponins 1-3 are new compounds.Objective To study the chemical structures of saponins in the rhizome of Cynanchum otophyllum（Asclepiadaceae）, and to find new compounds. Methods The total saponins of the rhizome were separated by silica gel column chromatography. The chemical structures of obtained compounds were determined by NMR and FAB-MS spectra. Results Three C21 steroidal saponins were separated. Their structures were determined as caudatin 3- O-β-D-glucopyranosyl-（1 →4）-β- D-digitoxopyranosyl-（1 → 4）-β-D-digino- pyranosyl-（1 -4）-α-D-oleandropyranoside （1）, caudatin 3-O-β-D-oleandropyranosyl- （1→4）-α-D-oleandropyranosyl-（1→4）-α-D-oleandropyranoside （2）, and caudatin 3-O- β-D-glucopyranosyl-（1 →4）-α-D-oleandropyranosyl-（1 -4）-β-D-diginopyranosyl-（1→4）- α-D-oleandropyranoside （3）, respectively. Conclusion Saponins 1-3 are new compounds.

关 键 词：ASCLEPIADACEAE Cynanchum otophy//um Czl steroidal saponins 

分 类 号：R284[医药卫生—中药学]