支气管哮喘儿童血清25羟维生素D3和白细胞介素17的关系  

Relationship between serum 25-dihydroxyvitamin D3 and interleukin-17 in children with bronchial asthma

作　　者：尹相府 林荣军[1] 胡素娟[1] 金蓉[1] 管仁政[1] 

机构地区：[1]青岛大学附属医院儿科,山东省青岛市266003

出　　处：《中国组织工程研究》2015年第B05期90-91,共2页Chinese Journal of Tissue Engineering Research

基　　金：青岛大学附属医院基金项目（11-2-4-2-（27）-jch）

摘　　要：背景：研究发现，白细胞介素17和25羟维生素D3在支气管哮喘发病中扮演着重要的角色。目的：探索儿童支气管哮喘中自细胞介素17和25羟维生素D3是否存在关系。方法：收集80例支气管哮喘儿童和20名正常对照儿童的血清样本，使用放免法和酶联免疫吸附方法测量血清中白细胞介素17和25羟维生素D3并分析两者的相关性。结果与结论：与对照组相比，哮喘组儿童血清中白细胞介素17表达水平显著升高（P〈0．01），而25羟维生素D3表达水平明显降低（P〈0．01），同时发现哮喘组儿童血清中自细胞介素17表达水平和25羟维生素D3表达水平呈负相关（P〈0．01）。说明白细胞介素17和25羟维生素D3在儿童支气管哮喘的发病中重要作用。BACKGROUND： Previous studies found that both interleukin-17 and 25-（OH） D3 play significant roles in asthma. OBJECTIVE： To find if there is any association between interleukin-17 and 25-（OH） D3 in childhood asthma. METHODS： Serum samples from 80 children with bronchial asthma and 20 normal children were collected. The levels of 25-（O1-1） Dz and interleukin-17 in serum were measured by radioimmunoassay and ELISA. In addition, the correlation between 25-（OH） D3 and interleukin-17 was analyzed. RESULTS AND CONCLUSION： Compared with the control group, the level of intedeukin-17 in the asthma group was higher significantly （P 〈 0.01）; however, the expression of 25 （OH） D3 was lower significantly （P 〈 0.01）. In the asthma group, we found that the two factors were negatively correlated in the, asthma group （P 〈 0.01 ）. The results suggest that intedeukin-17 and 25-（OH） D3 are rather important in the occurrence of childhpod asthma and display a significant clinical value to guide the treatment.

关 键 词：白细跑介素11 25二羟维生素D3 支气管哮喘 儿童 血清 

分 类 号：R725.914.4[医药卫生—儿科]