经皮肝瘤内注射术联合经导管肝动脉化疗栓塞术治疗中晚期肝癌的临床研究  

Clinical study of percutaneous liver tumor injection combined with transcatheter arterial chemoembolization in the treatment of advanced hepatocellular carcinoma

作　　者：程文元 戴振华 楼丽霞 丰云峰 

机构地区：[1]金华市第五医院普外科,浙江省金华321001

出　　处：《中国基层医药》2015年第15期2247-2250,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探讨经皮肝瘤内注射术联合经导管肝动脉化疗栓塞术治疗中晚期肝癌的临床疗效，为临床治疗方案的制定提供参考。方法选取中晚期肝癌患者22例，采用经皮肝瘤内注射术联合经导管肝动脉化疗栓塞术进行治疗，出院后每月随访1次。分析患者经皮肝瘤内注射术和经导管肝动脉化疗栓塞术的情况，同时分析患者随访过程中的生存时间、肿瘤体积和患者临床症状的变化情况。结果患者均于术后6周复查，其中，完全缓解6例，部分缓解8例，稳定6例，进展2例。随访发现，患者的生存时间为17～82个月，平均生存时间为（55．71±13．47）个月；治疗后4例肿瘤直径缩小1～3 cm，18例肿瘤直径缩小3～5 cm；19例肝区疼痛症状获得半年以上的缓解，3例肝区疼痛症状缓解时间不足6个月。随访期间有12例患者因多器官功能衰竭而死亡。Objective To study the effects of percutaneous liver tumor injection combined with the clinical efficacy of transcatheter hepatic artery chemoembolization in the treatment of advanced liver cancer,and to provide ref-erence for clinical treatment.Methods 22 patients using percutaneous liver tumor injection combined with transcath-eter arterial chemoembolization for treatment were selected,with which 1 month follow-up after discharge.Situation of patients with percutaneous liver tumor injection and transcatheter hepatic artery chemoembolization was analyzed,and the changes of the patients in the following -up of survival time,tumor volume and clinical symptoms were also ana-lyzed.Results Among the patients of postoperative recheck after 6 weeks,6 cases were complete remission,there were partial remission in 8 cases,6 cases of stable,2 cases of progress.Follow up to 2013 December,the patients＆#39;sur-vival time was 17-82 months,the average survival time was （55.71 ±13.47）months.After treatment,4 cases of patients＆#39;tumor diameter reduced 1 -3cm,18 cases of tumor diameter reduced 3 -5cm,19 cases of liver area pain symptoms for more than half a year of remission,3 cases of liver area pain relief time less than half a year.During the follow -up period,12 patients died of multiple organ failure.Conclusion The development of percutaneous liver tumor injection combined with transcatheter hepatic arterial chemoembolization therapy can delay the development of the disease in patients with advanced HCC,and prolong the survival time.

关 键 词：肝肿瘤 经皮肝瘤内注射术 经导管肝动脉化疗栓塞术 

分 类 号：R735.7[医药卫生—肿瘤]