不同给药顺序对苏芬太尼诱发呛咳反应的临床观察  

The clinical observation of different sequences of intravenous administration on sufentanyl-induced cough

作　　者：唐恩辉[1] 徐振兴[1] 翁浩[1] 

机构地区：[1]上海交通大学附属第六人民医院奉贤分院麻醉科,上海市201499

出　　处：《中国基层医药》2015年第15期2286-2288,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：评价全麻诱导时不同给药顺序对苏芬太尼诱发呛咳反应的影响。方法拟全麻下行择期手术患者100例，年龄20～60岁，体质量45～82 kg，ASA Ⅰ或Ⅱ级。采用随机数字表法分为两组，各50例。苏芬太尼-丙泊酚组（SP 组）静脉注射苏芬太尼0．4μg／kg，5 s 注射完毕，随即静脉注射丙泊酚2 mg／kg；丙泊酚-苏芬太尼组（PS 组）先静脉注射丙泊酚2 mg／kg，随即注射苏芬太尼0．4μg／kg，5 s 注射完毕。分别记录注射完苏芬太尼后1 min 内呛咳反应的发生情况、程度和出现时间。结果SP 组呛咳反应发生率为38％（19／50），高于 PS 组的12％（6／50），差异有统计学意义（χ2＝9．013，P ＜0．01）；SP 组呛咳反应出现时间为（20．6±5．8）s，PS 组为（18．8±8．4）s，两组呛咳反应出现时间差异无统计学意义（t ＝1．247，P ＞0．05）。结论与苏芬太尼-丙泊酚给药相比，丙泊酚-苏芬太尼给药可有效减少全麻诱导期间苏芬太尼诱发的呛咳反应。Objective To evaluate the effects of different sequences of intravenous administration on sufenta-nyl-induced cough during induction of general anesthesia.Methods One hundred patients,aged 20 ~60 years,weig-hing 45 ~82 kg,ASA Ⅰ or Ⅱ,scheduled for elective surgery under general anesthesia,were equally randomized to two groups by using a random number table：sufentanyl-propofol group（group SP）and propofol-sufentanyl group（group PS）.In group SP,sufentanyl 0.4μg/kg was injected intravenously over 5s,and then propofol 2mg/kg was injected intravenously.In group PS,propofol 2mg/kg was injected intravenously,and then sufentanyl 0.4μg/kg was injected intravenously over 5s.The occurrence,intensity and the time of cough were recorded within 1 min after sufentanyl injection.Results The incidence of cough was 38%（19 /50）in group SP which was significantly higher than the 12%（6 /50）in group PS（χ2 =9.013,P 〈0.01）;The time of cough was （20.6 ±5.8）s in group SP and （18.8 ± 8.4）s in group PS,which had no statistical significance（t =1.247,P 〉0.05）.Conclusion Administration in the propofol-sufentanyl sequence can effectively reduce the occurrence of sufentanyl-induced cough as compared with that in the sufentanyl-propofol sequence during induction of general anesthesia.

关 键 词：苏芬太尼 丙泊酚 呛咳反应 

分 类 号：R614[医药卫生—麻醉学]