卡维地洛和美托洛尔对高血压心脏病患者左室重塑及血清基质金属蛋白酶-9水平的影响  

The effect observation of carvedilol and metoprolol on MMP-9 changes and left ventricular remodeling in patients with hypertension heart disease

作　　者：周仙花 蔡宏文[2] 

机构地区：[1]浙江省松阳县人民医院内科,323400 [2]浙江省中医院心血管内科

出　　处：《中国基层医药》2015年第15期2352-2355,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：观察卡维地洛和美托洛尔对高血压心脏病左心室肥厚患者的效果，分析该治疗对血清基质金属蛋白酶-9（MMP-9）的影响。方法选取高血压心脏病患者共168例，依随机数字表法分为两组，对照组（84例）应用美托洛尔进行治疗，观察组（84例）应用卡维地洛进行治疗。观察治疗后舒张末期室间隔厚度（IVST）、舒张末期左室后壁厚度（LVPWT）、左室重量指数（LVMI）和左室球径指数（LVGI）的变化，同时观察血清 MMP-9的变化。结果两组治疗后 IVST、LVPWT、LVMI 和 LVGI 值均下降，血清 MMP-9的表达下降，但是观察组 IVST[（1．72±0．35）mm 比（0．36±0．11）mm，t ＝5．75，P ＜0．05]、LVPWT[（0．66±0．25）mm 比（0．24±0.18）mm，t ＝4．32，P ＜0．05]、LVMI[（16．23±3．35）g／m2比（7．44±2．24）g／m2，t ＝9．86，P ＜0．05]、LVGI[（0．52±0．12）g／m2比（0．40±0．11）g／m2，t ＝4．24，P ＜0．05]和 MMP-9[（76．23±20．87）比（42．55±10．87），t ＝6．54，P ＜0．05]下降值明显均明显高于对照组。结论卡维地洛对高血压心脏病患者心室重塑的作用明显，且对血清 MMP-9的表达有降低作用。Objective To study the curative effect of MMP-9 changes on left ventricular hypertrophy patients with hypertension heart disease by carvedilol and metoprolol.Methods 168 cases were divided into two groups.The control group（84 cases）applied metoprolol.The observation group applied carvedilol.The changes of IVST,LVPWT, LVMI and LVGI,expression of MMP-9 were observed in two groups after treatment.Results The values of IVST, LVPWT,LVMI and LVGI,expression of MMP-9 were decreased after treatment.But the decreased values of IVST [（1.72 ±0.35 ）mm vs （0.36 ±0.11 ）mm,t =5.75,P 〈0.05 ],LVPWT[（0.66 ±0.25 ）mm vs （0.24 ± 0.18）mm,t =4.32,P 〈0.05],LVMI[（16.23 ±3.35）g/m2 vs （7.44 ±2.24）g/m2 ,t =9.86,P 〈0.05 ],LVGI [（0.52 ±0.12）g/m2 vs （0.40 ±0.11）g/m2 ,t =4.24,P 〈0.05],MMP-9[（76.23 ±20.87）vs（42.55 ±10.87）,t =6.54,P 〈0.05]were higher in the observation group than in the control group.Conclusion The treatment of carvedilol is satisfied,can improve ventricular remodeling,decreased the expression of MMP-9,and is worthy of being recommended in left ventricular hypertrophy patients with hypertension heart disease.

关 键 词：高血压 心脏疾病 基质金属蛋白酶类 卡维地洛 美托洛尔 

分 类 号：R541.3[医药卫生—心血管疾病]