苏皖地区PCSK9基因E670G位点多态性与急性心梗相关性研究  

A study on the correlation between E670G polymorphism of PCSK9 gene and acute myocardial infarction in the Suwan (Jiangsu and Anhui) area population

作　　者：杨春[1] 徐军[1] 肖继明[1] 殷宇刚[1] 郭华[1] 杨翔 

机构地区：[1]南京军区南京总医院干部心内科老年病研究中心,南京210002 [2]南京军区干部病区32病区老年病研究中心,南京210002

出　　处：《中国优生与遗传杂志》2015年第8期13-14,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的研究苏皖地区PCSK9基因位点E670G位点多态性与急性心肌梗死的相关性。方法采集2012-2014年心肌梗死病患血液标本160例,健康人血液标本182例;分别提取基因组DNA,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测苏皖地区急性心肌梗死患者PCSK9基因E670G的分布情况,并分析该位点与急性心肌梗死的关系。结果本研究患者中尚未发现E670G多态性位点;位点等位基因频率基因型频率分布差异无统计学意义(P>0.05)。结论苏皖地区汉族AMI患者和健康人群在该位点的基因型频率和等位基因分布差异不明显,尚未发现PCSK9基因E670G多态性与AMI之间存在相关性。Objective：Examined the E670 G polymorphism of PCSK9 gene in patients with acute myocardial infarction（AMI）and healthy people in Suwan area by PCR-RFLP. Methods：Blood samples from 160 cases of AMI diagnosed and 182 cases of normal blood samples were studied.Genomic DNA was amplified by PCR.Results：The allele and genotype frequency of AMI patients was not significantly higher than the healthy individual（P0.05）. Conclusion：The E670 G polymorphism of the PCSK9 gene is not associated with the the severity of acute myocardial infarction in the Suwan area population

关 键 词：急性心肌梗死 PCSK9基因 E670G 多态性 低密度脂蛋白胆固醇 

分 类 号：R541.4[医药卫生—心血管疾病]