Recent progress of sugar amino acids: Synthetic strategies and applications as glycomimetics and peptidomimetics  

作　　者：Guang-Zong Tian Xiao-Li Wang Jing Hu Xue-Bin Wang Xiao-Qiang Guo Jian Yin 

机构地区：[1]Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education, School of Biotechnology, Jiangnan University [2]Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University [3]Wuxi Medical School, Jiangnan University

出　　处：《Chinese Chemical Letters》2015年第8期922-930,共9页中国化学快报（英文版）

基　　金：supported by the National Science Foundation for Young Scientists of China(No.21302068);the Natural Science Foundation of Jiangsu Province,China(No.BK20130127);Jiangsu Province‘‘Six Summit Talent’’Foundation(No.2012-SWYY-009);the Specialized Research Fund for the Doctoral Program of Higher Education(No.20120093120002);the Fundamental Research Funds for the Central Universities(Nos.JUSRP51319B,JUSRP51411B)

摘　　要：In order to meet the increasing demands for the development of large varieties of new molecules for discovering new drugs and materials, organic chemists are developing many novel multifunctional building blocks, which are assembled rationally to create ‘nature-like＇ and yet unnatural organic molecules with well-defined structures and useful properties. Sugar amino acids（SAAs）, the carbohydrate derivatives bearing both amino and carboxylic acid functional groups, are important ones of these multifunctional building blocks, which can be used to create novel materials with potential applications as glycomimetics and peptidomimetics. This review will focus on recent synthetic strategies of SAAs and their applications in creating large number of structurally diverse glycomimetics and peptidomimetics.In order to meet the increasing demands for the development of large varieties of new molecules for discovering new drugs and materials, organic chemists are developing many novel multifunctional building blocks, which are assembled rationally to create ‘nature-like＇ and yet unnatural organic molecules with well-defined structures and useful properties. Sugar amino acids（SAAs）, the carbohydrate derivatives bearing both amino and carboxylic acid functional groups, are important ones of these multifunctional building blocks, which can be used to create novel materials with potential applications as glycomimetics and peptidomimetics. This review will focus on recent synthetic strategies of SAAs and their applications in creating large number of structurally diverse glycomimetics and peptidomimetics.

关 键 词：structurally carboxylic oligomer blocks assembled Fmoc amide carbohydrate diverse protected 

分 类 号：O629.711[理学—有机化学]