Antiviral enantiomers of a bisindole alkaloid with a new carbon skeleton from the roots of Isatis indigotica  

作　　者：Yu-Feng Liu Ming-Hua Chen Xiao-Liang Wang Qing-Lan Guo Cheng-Gen Zhu Sheng Lin Cheng-Bo Xu Yue-Ping Jiang Yu-Huan Li Jian-Dong Jiang Yan Li Jian-Gong Shi 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College [2]Jining Medical University [3]Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College

出　　处：《Chinese Chemical Letters》2015年第8期931-936,共6页中国化学快报（英文版）

基　　金：Financial support from the National Natural Science Foundation of China(NNSFC;Nos.81373287 and 30825044);the Program for Changjiang Scholars and Innovative Research Team in University(PCSIRT,No.IRT1007);the National Science and Technology Project of China(Nos.2012ZX09301002-002 and 2011ZX0 9307-002-01)

摘　　要：A pair of indole alkaloid enantiomers with a novel bisindolylacetamide skeleton, insatindibisindolamides A and B（1a and 1b）, was isolated from an aqueous extract of Isatis indigotica roots. The enantiomers were separated by chiral HPLC. Their structures and absolute configurations were elucidated by extensive spectroscopic analysis, including 2D NMR, X-ray crystallography, and electronic CD（ECD） calculation. The proposed biosynthetic pathway and preliminary investigations of the biological activity of compounds 1a and 1b are also discussed.A pair of indole alkaloid enantiomers with a novel bisindolylacetamide skeleton, insatindibisindolamides A and B（1a and 1b）, was isolated from an aqueous extract of Isatis indigotica roots. The enantiomers were separated by chiral HPLC. Their structures and absolute configurations were elucidated by extensive spectroscopic analysis, including 2D NMR, X-ray crystallography, and electronic CD（ECD） calculation. The proposed biosynthetic pathway and preliminary investigations of the biological activity of compounds 1a and 1b are also discussed.

关 键 词：Isatis alkaloid spectroscopic elucidated skeleton separated indole preliminary absolute COSY 

分 类 号：TQ460.1[化学工程—制药化工]