Solvent free synthesis of trifluoromethyl tertiary alcohols by cross Aldol reaction  

作　　者：Rui Tao Xue-Jiao Yin Ke-Hu Wang Yu-Zhuo Niu Ya-Lin Wang Dan-Feng Huang Ying-Peng Su Jin-Xian Wang Yu-Lai Hu Ying Fu Zheng-Yin Du 

机构地区：[1]College of Chemistry and Chemical Engineering, Northwest Normal University

出　　处：《Chinese Chemical Letters》2015年第8期1046-1049,共4页中国化学快报（英文版）

基　　金：financial support from the National Natural Science Foundation of China(No.21262031);Bioactive Product Engineering Research Center for Gansu Distinctive Plants;State Key Laboratory of Applied Organic Chemistry,Lanzhou University

摘　　要：Exceedingly fast preparation of trifluoromethyl tertiary alcohols has been accomplished from methyl ketones and trifluoromethyl ketones under solvent free conditions by cross Aldol reaction. The reaction was achieved in the presence of common inorganic base by grinding method at ambient temperature to give b-trifluoromethyl-b-hydroxyl ketones in high yields（up to 95%）.Exceedingly fast preparation of trifluoromethyl tertiary alcohols has been accomplished from methyl ketones and trifluoromethyl ketones under solvent free conditions by cross Aldol reaction. The reaction was achieved in the presence of common inorganic base by grinding method at ambient temperature to give b-trifluoromethyl-b-hydroxyl ketones in high yields（up to 95%）.

关 键 词：alcohols tertiary ambient hydroxyl inorganic smoothly accomplished silica heterocyclic reagent 

分 类 号：TQ223.1[化学工程—有机化工]