2型糖尿病合并冠状动脉粥样硬化性心脏病患者下肢血管病变相关因素分析  

Analysis of risk factors for lower extremity atherosclerotic disease in patients with type 2 diabetes combined with coronary atherosclerotic heart disease

作　　者：舒毅[1] 陈幼萍[1] 曾春平[1] 李惠贤[1] 罗少荘[1] 罗海钊[1] 梁蕴谊[1] 

机构地区：[1]南方医科大学附属广东南海人民医院内分泌科,广东佛山528200

出　　处：《新乡医学院学报》2015年第8期785-787,共3页Journal of Xinxiang Medical University

摘　　要：目的探讨糖尿病合并冠状动脉粥样硬化性心脏病患者下肢血管病变(LEAD)的患病情况及其相关因素。方法选择108例确诊为2型糖尿病合并冠状动脉粥样硬化性心脏病患者进行踝臂指数(ABI)测定,ABI≤0.9的患者为LEAD组,0.9<ABI≤1.3的患者为非LEAD组,分别对2组患者进行临床特征比较,并对LEAD危险因素作logistic回归分析。结果 108例患者中,非LEAD组患者67例,LEAD组患者41例,LEAD患病率为38.0%。与非LEAD组患者比较,LEAD组患者年龄、糖尿病病程、空腹血糖、糖化血红蛋白(Hb A1c)、三酰甘油(TG)及高敏C反应蛋白均较高(P<0.05),吸烟率及合并高血压病患者患病率更高(P<0.05)。Logistic回归分析显示,年龄、糖尿病病程、高血压、Hb A1c及TG为LEAD发生的独立危险因素。结论糖尿病合并冠状动脉粥样硬化性心脏病患者LEAD的患病率较高,临床上应重视LEAD筛查及危险因素控制。Objective To explore the prevalence of lower extremity atherosclerotic disease （LEAD） and its related risk factors in patients with type 2 diabetes （T2DM） combined with coronary atherosclerotic heart disease （CHD）. Methods An- kle-brachial index （ABI） was measured in 108 inpatients with T2DM combined with CHD. Inpatients were divided into two groups base on ABI values ： LEAD group with ABI ≤0.9 and NLEAD group with 0.9 〈 ABI ≤ 1.3. The clinical features of two groups were compared, and analyzed by the method of logistic regression. Results NLEAD group comprised 67 cases and LEAD group comprised 41 cases in 108 inpatients. The prevalence rate of LEAD was 38.0%. Age, diabetes duration, fasting blood glucose, glycosylated hemoglobin（ HbA1 c ） , triglyceride （TG） , and high sensitive C-reactive protein in LEAD group were higher than those in NLEAD group （ P 〈 0.05 ）. The smoking rate and morbidity of hypertension in LEAD group were markedly higher than those in NLEAD group （ P 〈 0.05 ）. Logistic regression analysis showed that age, diabetes duration, hypertension, HbAlc and TG were independent risk factors in LEAD. Conclusions The prevalence rate of LEAD in patients with T2DM combined with CHD is high. Clinicians should pay attention to screening and strengthen the control of risk factors of LEAD.

关 键 词：2型糖尿病 冠状动脉粥样硬化性心脏病 下肢血管病变 踝臂指数 

分 类 号：R587.2[医药卫生—内分泌]