代谢综合征与泌尿系结石复发关系的研究  

Correlation of metabolic syndrome with recurrence of urolithiasis

作　　者：陈星[1,2] 郭剑明[1] 王国民[1] 徐志兵[1] 王杭[1] 

机构地区：[1] 中日友好医院泌尿外科 [2] 复旦大学附属中山医院泌尿外科,上海200032

出　　处：《中华泌尿外科杂志》2015年第8期624-627,共4页Chinese Journal of Urology

摘　　要：目的 研究代谢综合征（metabolic syndrome,MS）与泌尿系结石复发之间的相关性.方法 回顾性分析2008年3月至2012年2月住院治疗的泌尿系结石患者资料,采用2007年中国成人血脂异常防治指南制订联合委员会修订后的MS诊断标准将患者分为MS组和非MS组.随访24～ 72个月,中位时间47个月,分析两组患者结石复发情况的差异.结果 共纳入218例泌尿系结石患者,其中52例伴有MS.MS组29例（55.8％）出现泌尿系结石复发,非MS组为66例（39.8％）,差异有统计学意义（P =0.042）.Kaplan-Meier曲线显示,MS组中位复发间隔为36个月,非MS组为59个月（Log-rank检验,P=0.019）.多元Cox回归模型分析结果显示,MS与泌尿系结石复发相关（HR=1.817,95％CI1.105～2.988,P=0.011）,而性别（P =0.336）、年龄（P =0.246）及初次就诊时是否为复发性泌尿系结石（P=0.051）与泌尿系结石复发不相关.结论 MS是泌尿系结石复发的独立危险因素.对于合并MS的结石患者,预防结石复发时应重视MS的治疗.Objective To investigate the relationship between metabolic syndrome （MS） and recurrence of urolithiasis.Methods A retrospective analysis was performed in urinary stone patients from March 2008 to February 2012.Patients were divided into MS group and non-MS group according to the diagnose criteria of metabolic syndrome （2007 version） by the joint committee for developing Chinese guidelines on prevention and treatment of dyslipidemia in adults.The patients were followed up for 24-72months （median 47 months） since operation.The difference of stone recurrence was compared between the 2 groups.Results Two hundred and eighteen patients with urinary stone disease were enrolled.Of them,52 patients were diagnosed with MS.Stone recurrence occurred in 29 patients （55.8%） of MS group,whereas 66 patients （39.8%） of non-MS group suffered stone recurrence.It demonstrated the median recurrence free survival of group MS and non-MS was 36 months and 59 months by Kaplan-Meier analysis,respectively （Log-rank test,P =0.019）.Multivariate Cox regression analysis results revealed that MS was significantly associated with stone recurrence （HR 1.817,95% CI 1.105-2.988,P =0.011）,however,the gender （P =0.336）,age （P =0.246） and recurrence urolithiasis at first visit （P =0.051） were not associated with stone recurrence.Conclusions MS is an independent risk factor for urinary stone recurrence.It is suggested that the treatment of MS may have a important role in prevention of stone recurrence in MS patients with urolithiasis.

关 键 词：代谢综合征 尿路结石 复发 

分 类 号：R589[医药卫生—内分泌] R691.4[医药卫生—内科学]