以鹿茸为模型探索软骨组织发生  

Exploration of Cartilage Development Using Deer Antler Model

作　　者：路晓[1] 孙红梅[1] 张伟[1] 李春义[1] 

机构地区：[1]中国农业科学院特产研究所,特种经济动物分子生物学国家重点实验室,长春130000

出　　处：《中国农业科技导报》2015年第4期71-77,共7页Journal of Agricultural Science and Technology

基　　金：国家863计划项目(2011AA100603);国家自然科学基金项目(31170950)资助

摘　　要：软骨组织的研究一直依赖于哺乳动物胚胎模型,这种方法存在取材困难、难以明确界定分层边界等弊端。而鹿茸非常独特,可以作为一种新的生物医学模型对软骨发育进行研究。通过比较传统的软骨研究模型和鹿茸这种新型模型,分析了鹿茸作为软骨研究模型的优势,同时对鹿茸软骨组织发生与生长的组织基础,以及分子调控机制的研究进展进行了综述,并对鹿茸软骨组织中血管生成的调控因子进行了探讨,以期为寻找更有效的软骨发育研究模型提供理论参考。Studies on cartilage tissues has been relying on embryo model of mammals. This method has difficuhies in obtaining material and clearly defining layered boundaries. While, the antler is unique that can be used as a new biomedicine model to study cartilage development. Through comparing the traditional cartilage research model with the new antler model, this paper analyzed the advantages of antlers being a new cartilage research model; reviewed the turning up of antler cartilage and tissue foundation of its growth, and molecular regulation mechanism; discussed the regulatory factors in angiogenesis of antler cartilage, so as to provide theoretical basis for finding a more effective model in studying cartilage development.

关 键 词：鹿茸 软骨发生 调控机制 

分 类 号：Q959.9[生物学—动物学]