低分子肝素与银杏达莫注射液联合应用改善急性心源性脑栓塞患者神经功能缺损的临床观察  

Therapeutic Efficacy of Low Molecular Heparin plus Ginkgo Leaf Extract and Dipyridamole Injection for Neurologic Impairment in Patients with Acute Cardiogenic Cerebral Embolism

作　　者：李海燕[1] 高月娟[1] 林洋洋[2] 徐丹[3] 丛军兹[1] 

机构地区：[1]牡丹江医学院红旗医院药学部,黑龙江牡丹江157011 [2]牡丹江医学院红旗医院口腔科,黑龙江牡丹江157011 [3]牡丹江医学院红旗医院神经内一科,黑龙江牡丹江157011

出　　处：《中国医院用药评价与分析》2015年第7期939-940,共2页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨低分子肝素与银杏达莫注射液联合用于改善急性心源性脑栓塞患者神经功能缺损的临床效果。方法:选取2013年1月—2014年12月牡丹江医学院红旗医院收治的40例急性心源性脑栓塞患者,以随机数字表法分为观察组和对照组各20例。对照组患者采用基础治疗联合低分子肝素治疗,观察组患者在基础治疗的基础上给予低分子肝素联合银杏达莫治疗,对比2组患者治疗前后神经功能缺损评分和临床疗效。结果:观察组患者治疗3 d、1周、2周的神经功能缺损评分分别为(18.80±6.13)、(17.34±6.17)、(15.89±5.57)分,均明显低于对照组的(20.99±7.12)、(20.87±7.42)、(18.38±7.20)分,差异均有统计学意义(P<0.05);观察组患者的总有效率为95.00%(19/20),明显高于对照组的75.00%(15/20),差异有统计学意义(P<0.05)。结论:采用低分子肝素联合银杏达莫治疗急性心源性脑栓塞,能明显改善患者的神经功能缺损情况,值得在临床上推广。OBJECTIVE： To explore the therapeutic efficacy of low molecular weight heparin（ LMWH） plus Ginkgo Leaf Extract and Dipyridamole Injection for neurologic impairment in patients with acute cardiogenic cerebral embolism. METHODS： 40 patients with acute cardiac cerebral embolism in Mudanjiang Medical College Hongqi Hospital from January 2013 to December 2014 were randomly divided into observation group and control group with 20 cases each. The patients in the control group were treated with routine therapy plus low molecular heparin,while those in the observation group were treated with routine therapy plus low molecular heparin and Ginkgo Leaf Extract and Dipyridamole Injection. The two groups were evaluated with regard to neurologic impairment scores and clinical efficacy. RESULTS： At 3 days,1 and 2 weeks,the neurologic impairment scores in the observation group were significantly lower than in the control group [（ 20. 99 ± 7. 12）,（ 20. 87 ± 742）,（ 18. 38 ± 720）,respectively of the observation group vs.（ 18. 80 ± 6. 13）,（ 17. 34 ± 6. 17）,（ 15. 89 ± 5. 57,respectively of the control group）（ P〈0. 05）; the total effective rate in the observation group was significantly higher than in the control group[95%（ 19 /20）vs. 75%（ 15 /20）,P〈0. 05]. CONCLUSIONS： Treatment of patients with acute cardiogenic cerebral embolism using low molecular weight heparin plus Ginkgo Leaf Extract and Dipyridamole Injection resulted in significant improvement of neurologic impairment,therefore,its use is worthy of clinical recommendation.

关 键 词：低分子肝素 银杏达莫注射液 急性心源性脑栓塞 神经功能缺损 

分 类 号：R972[医药卫生—药品]