妊娠期高血压疾病患者血小板参数和凝血功能指标的变化及意义  

Changes and significance of platelet parameters and blood coagulation function index in patients with hypertensive disorder complicating pregnancy

作　　者：史玉霞[1] 杨一新[2] 许倩[2] 朱燕华[1] 

机构地区：[1]无锡市妇幼保健院妇产科,江苏无锡214000 [2]无锡市妇幼保健院产科,江苏无锡214000

出　　处：《海南医学院学报》2015年第10期1384-1386,共3页Journal of Hainan Medical University

基　　金：江苏省科技支撑计划(BE2013343)~~

摘　　要：目的:探讨妊娠期高血压疾病(HDCP)患者血小板参数和凝血功能指标的变化及意义。方法:选择89例HDCP患者,设为HDCP组,另选择健康妊娠晚期妇女60例和健康非孕妇女42例,分别设为晚孕对照组和非孕对照组,检测各组血小板参数:血小板平均体积(MPV)、血小板计数(PLT)、血小板分布宽度(PDW)和凝血指标:血浆凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(FIB)、D-二聚体(D-D)、活化部分凝血活酶时间(APTT)。结果:HDCP组PLT明显低于晚孕对照组和非孕对照组,而MPV和PDW明显高于两组,差异具有统计学意义(P<0.05);晚孕对照组PLT显著低于非孕对照组,差异具有统计学意义(P<0.05);HDCP组PT、APTT低于晚孕对照组和非孕对照组,而FIB、D-D高于两组,差异具有统计学意义(P<0.05);晚孕对照组PT、APTT低于非孕对照组,FIB、D-D高于非孕对照组,差异具有统计学意义(P<0.05)。结论:HDCP存在血小板活化现象和明显的高凝状态,动态检测HDCP患者血小板参数和凝血指标对于预防相关并发症的发生,提高产科安全性具有重要意义。Objective： To explore changes and significance of platelet parameters and blood coagulation function index in patients with hypertensive disorder complicating pregnancy. Methods： Chose 89 patients with HDCP as HDCP group, chose another 60 cases health late pregnancy women and 42 cases non pregnant female as late pregnant group and non pregnant con- trol group, detected the platelet parameters including the average blood platelet count （PLT）, platelet volume （MPV）, platelet distribution width （PDW） and blood coagulation indexes, plasma prothrombin time （PT）, thrombin time （TT）, fibrinogen （FIB）, D-dimer （D-D）, activated partial blood coagulation time （APTT） live enzymes in three groups. Results： 1. Compared with the non pregnant group and late pregnant group, PLT was significantly lower, while the MPV and PDW were significant- ly higher in HDCP group （all P〈0.05）. PLT in late pregnant group was significantly lower than that in non pregnant group （P〈0. 05）, and there were no significantly difference in MPV and PDW between the two groups （P〈0.05） ; 2. Compared with the non pregnant group and late pregnant group, PT and APTT levels were significantly lower, while FIB and D-D were significantly higher in HDCP group （all P〈0.05）; The level of PT and APTT in late pregnant group were significantly lower, and FIB and D-D levels were significantly higher than that in non pregnant group （all P〈0.05）, However, The level of TT were not significant different among the three groups （P〈0.05）. Conclusion： For patients with HDCP, phenomenon of platelet activation and apparent high coagulation state exist, dynamic detection platelet parameters and blood coagulation indexes in HDCP patients in order to prevent related complications, improve obstetrics safety is of great significance.

关 键 词：妊娠期高血压疾病 血小板参数 凝血功能 

分 类 号：R714.2[医药卫生—妇产科学]