补气活血药对肿瘤血管生成的影响  

Effect of Qi-reinforcing and Blood-activating Medication on Tumor Angiogenesis

作　　者：臧文华[1] 郅琳[1] 唐德才[2] 

机构地区：[1]河南省南阳理工学院张仲景国医学院,南阳473004 [2]南京中医药大学基础医学院,南京210023

出　　处：《世界科学技术-中医药现代化》2015年第6期1300-1304,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委面上项目(81073072):基于活体成像技术的补气活血药配伍抗卵巢癌转移的时效关系研究;负责人:唐德才;国家自然科学基金委面上项目(81373990):黄芪;莪术配伍调控肝癌血管生成的体视学及分子机制研究;负责人:唐德才;河南省教育厅高校重点科研项目(15A360011):基于HGF/c-met信号通路的黄芪;莪术配伍调控肝癌血管生成的分子机制研究;负责人:臧文华

摘　　要：血管新生是肿瘤生长、侵袭、转移过程中的一个重要环节,以肿瘤新生血管为靶向的肿瘤治疗策略已成为目前肿瘤学研究的热点。肿瘤血管生成的信号传导是一个复杂、多因素、多途径、交叉的网络系统,针对某一个单一靶点往往不足以遏制或扭转其结构的高度异质及形态异常。因此,不同作用通路和机制的药物多靶点联合作用于肿瘤血管生成的信号通路,将是今后一个重要的研究方向。大量实验研究发现,许多补气活血药配伍在肿瘤新生血管生成中能发挥多靶点、多途径的调节作用,作用于肿瘤血管生成的不同环节而发挥抗肿瘤侵袭、转移作用,在治疗肿瘤及新生血管方面具有广阔的研究前景。Angiogenesis is an important link of tumor growth, invasion and metastasis. The tumor angiogenesis targeting strategy for the treatment of cancer has become a hot spot in oncology research currently. Signal transduction of tumor angiogenesis is a complex, multi-factor, multi-way and cross network system. Treatment for a single target is often not sufficient to halt or reverse its highly heterogeneous structure and abnormal shape. Therefore, it will be an important research direction that the combination of different pathways and mechanisms of medications effect on signaling pathway in tumor angiogenesis by multi-target. A number of experimental studies found that qi-reinforcing and blood-activating medication can play a regulating role of multiple targets, multiple pathways in tumor angiogenesis. It had different effect on tumor angiogenesis against tumor invasion and metastasis. Qi-reinforcing and blood-activating medication will have broad prospects in the treatment of tumor and angiogenesis.

关 键 词：补气活血药 中药配伍 肿瘤 新生血管 血管内皮细胞 

分 类 号：R273[医药卫生—中西医结合]