血液病患者输血前免疫血液学检查情况分析与探讨  

Analysis and discussion of pre-transfusion immunohematology testing of patients with hemopathic diseases

作　　者：潘凌子[1] 王霓[1] 邵林楠 宋文倩[1] 马杰[1] 周世航[1] 

机构地区：[1]大连市血液中心血型室,辽宁大连116001

出　　处：《临床血液学杂志（输血与检验）》2015年第4期649-651,共3页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的:回顾分析本地区ABO血型定型困难,红细胞不规则抗体与血小板抗体阳性在血液病患者中的发生状况,探讨其输血前检查的难点与重点。方法:使用试管法对标本进行ABO正反定型、抗体鉴定,使用固相凝集方法进行血小板抗体筛查。结果:血液病患者ABO血型正反定型的凝集强度易发生改变导致定型困难,自身与同种抗体常单独或同时存在导致供受者红细胞与血小板的不相配合,血型异常与抗体阳性的情况与血液病的种类有关。结论:血液病患者易发生血型异常、易产生红细胞与血小板抗体,应结合其病史和输血史分析输血前检查结果选择适合的血液,保证临床输血安全。Objective：To retrospectively analyze that the data of patients with hemopathic diseases in DaLian whose ABO blood typing discrepancy and positive reaction of red blood cell irregular antibodies screening and platelet antibodies,and discuss the difficulties and emphases of those immunohematology testing.Method：ABO typing and antibodies identification were detected using routine tube method that,and antibodies screening of platelet was tested by solid-phase coombs method.Result：ABO blood typing discrepancy was mainly caused by intensity change of the agglutination reaction.Autoantibody and alloantibody often existed singly or together,which led to incompatibility of red blood cell and platelet between donors and recipients,all of which were also related to the kinds of diseases.Conclusion：According to the result of immunohematology testing,which medical and transfusion history should also be concerned,suitable blood might be chosen for patients with hemopathic diseases to ensure clinical transfusion safety.

关 键 词：血液病 ABO定型 不规则抗体 血小板抗体 

分 类 号：R552[医药卫生—血液循环系统疾病]