心肌标志物对急性心肌梗死的临床诊断价值  

Clinical diagnostic value of myocardial markers on acute myocardial infarction

作　　者：严家来[1] 盛大平[2] 

机构地区：[1]安徽医学高等专科学校,合肥230601 [2]安徽医科大学第一附属医院

出　　处：《齐齐哈尔医学院学报》2015年第20期2978-2980,共3页Journal of Qiqihar Medical University

基　　金：中央财政支持高等职业学校提升专业服务能力项目(教职成[2011]11号);安徽省示范实验中心建设项目(2013sxzx027);安徽省质量工程项目(2014jyxm451)

摘　　要：目的探讨心肌血清标志物对急性心肌梗死的临床诊断价值。方法选取心内科因胸痛收治的心肌梗死的病人55例,进行心肌肌钙蛋白(c Tn I)、肌酸激酶同工酶(CK-MB)检测。结果急性心肌梗死组(AMI)血清CK-MB、c Tn I浓度均在发病后几小时内显著升高,均高于非AMI组(P<0.05),其中CK-MB的特异性为72.13%,敏感性为89.56%;c Tn I的特异性为95.26%,敏感性为86.14%;对AMI的诊断特异性c Tn I最高,而敏感性则是CK-MB最高。结论 c Tn I可作为急性心肌梗死的早期快速诊断指标,但需结合CK-MB联合检测。Objective To investigate the clinical diagnostic value of serum cardiac markers in patients with acute myocardial infarction. Methods 55 myocardial infarctionpatients who were admitted in department of cardiology because of chest pain were selected,cardiac troponin（ c Tn I） and creatine kinase isoenzyme（ CK-MB）levels were detected. Results Serum levels of CK-MB and c Tn I in acute myocardial infarction group（ AMI）increased significantly within a few hours after the onset of the disease,which were higher than those in non AMI group（ P〈0. 05）. The specificity of CK-MB was 72. 13% and the sensitivity was 89. 56%. The specificity of c Tn I was 95. 26% and the sensitivity was 86. 14%. c Tn I had the highest specificity in diagnosing AMI,however,CK-MBpresent the maximum sensitivity. Conclusions Tn I can be used as rapid diagnosis of early acute myocardial infarction index,but it should combine with the detection of CK-MB.

关 键 词：心肌标志物 急性心肌梗死 心肌肌钙蛋白I 

分 类 号：R542.22[医药卫生—心血管疾病]