成人隐匿性自身免疫性糖尿病与2型糖尿病患者抑郁症患病比较  

Comparison of the prevalence of the depression in adults with latent autoimmune diabetes and type 2 diabetes mellitus

作　　者：王书畅[1] 蔡文祎 王战建[3] 刘宽芝[3] 杨丽[4] 潘慧[1] 

机构地区：[1]北京协和医院内分泌科,北京100730 [2]迁安市人民医院检验科,河北迁安064400 [3]河北医科大学第三医院内分泌一科,河北石家庄050051 [4]河北医科大学第三医院心理科,河北石家庄050051

出　　处：《中国卫生检验杂志》2015年第15期2516-2518,2524,共4页Chinese Journal of Health Laboratory Technology

基　　金：河北省科技支撑计划项目(122777154)

摘　　要：目的探讨成人隐匿性自身免疫性糖尿病(LADA)与2型糖尿病(T2DM)患者的生物心理因素的异同及其与血糖控制的相关关系。方法用病例-对照的研究方法分析LADA与T2DM患者抑郁的情感因素差异及其与血糖控制的关系。结果 LADA患者抑郁症的患病率较T2DM患者明显增加;HAMD量表评分比较,除日夜变化评分外,其余变量在LADA患者均显著高于T2DM患者;LADA合并抑郁症患者的HAMD评分较T2DM中抑郁症患者HAMD评分显著增高;LADA患者较T2DM患者的脆性糖尿病发生率明显增加;LADA合并抑郁症的患者与LADA未合并抑郁症的患者出现脆性糖尿病的风险差异无统计学意义(P>0.05)。结论 LADA患者抑郁症的患病率及其病情严重程度均较T2DM患者增加,LADA患者患抑郁症与否与发生脆性糖尿病风险无明显相关性,抑郁症未增加LADA患者出现脆性糖尿病的风险。Objective To investigate similarities and differences of the psychological factors of depression and its correlation with blood glucose control between latent autoimmune diabetes in adults（ LADA） and type 2 diabetes mellitus（ T2DM）. Methods Using a case- control study to analyze the differences of depression between LADA and T2 DM and the correlation between depression and glucose level among these people. Results The prevalence of depression and its severity in LADA patients increased significantly than that in T2 DM patients. Except for the diurnal variation,all the other scores of the variables in Hamilton Rating Scale for Depression（ HAMD） in LADA patients were higher when compared with those in T2 DM patients; HAMD score of LADA with depression was significantly higher than that of HAMD in T2 DM. The incidence of brittle diabetes in LADA patients increased significantly compared with that in T2 DM patients. There was no significant difference in the risk of brittle diabetes between LADA patients with and without depression（P〈0. 05）. Conclusion The prevalence of depression and its severity LADA patients increased significantly than that of T2 DM patients. There was no obvious correlation between depression and brittle diabetes among LADA patients. Depression did not increase the risk of brittle diabetes in LADA patients.

关 键 词：成人隐匿性自身免疫性糖尿病 谷氨酸脱羧酶抗体 抑郁症 脆性糖尿病 动态血糖监测 

分 类 号：R587.1[医药卫生—内分泌]