贵州荔波地区人群肝功能及乙肝感染调查  

Investigation on liver function and hepatitis B infection population in Libo area of Guizhou

作　　者：邓成敏[1] 何燕[1] 张婷[1] 邓婕[1] 吴昌学[1] 官志忠[1] 

机构地区：[1]贵阳医学院分子生物学重点实验室,贵州贵阳550004

出　　处：《中国卫生检验杂志》2015年第15期2613-2615,2618,共4页Chinese Journal of Health Laboratory Technology

基　　金：国家"十二五"科技支撑计划项目(2013BAI05B03)

摘　　要：目的调查贵州省荔波地区人群的肝功能状况及乙型病毒性肝炎感染的情况。方法应用全自动分析仪检测肝功能相关指标以及用酶联吸附试验（ELISA）检测乙肝5项指标并进行分析。结果荔波地区男性肝功能指标异常率大于女性,中年龄组丙氨酸氨基转移酶（ALT）异常率高于低年龄组和高年龄组。HBs Ag、抗-HBs、HBe Ag、抗-HBe、抗-HBc阳性率分别为10.37%、27.53%、0.58%、26.61%、36.98%,抗-HBs阳性率在10岁～19岁组最高（40.63%）。HBV感染模式以模式Ⅰ（5项血清学标志物均阴性）和模式Ⅱ（仅抗-HBs阳性）最多。结论荔波地区男性肝损伤大于女性,而中年龄组肝损伤也大于低年龄组和高年龄组,且低年龄组对HBV感染的抵抗力大于高年龄组。为了阻断HBV的传播,应结合肝功能指标做到早期预防、及时治疗来提高人群的健康状况。Objective To investigate the liver function and hepatitis B virus infection populations of Libo,Guizhou. Methods Related indicators of liver function were detected by automatic chemistry analyzer and 5 hepatitis B indicators were detected by enzyme linked innunosorbent assay（ ELISA） and then were and analyzed. Results Men liver function abnormalities rate was more than women in Libo. Alanine aminotransferase（ ALT） abnormal rate of the middle- age group was higher than the low-age group and high- age groups. The positive rate of HBs Ag,anti- HBs,HBe Ag,anti- HBe,anti- HBc was 10. 37%,27. 53%,0. 58%,26. 61%,36. 98%,respectively. The highest positive rate of anti- HBs was 10- 19 years old（ 40. 63%）. The major models of HBV infection were model Ⅰ（ all of the five serum markers were were negative） and modelⅡ（ only anti anti- HBs was positive）. Conclusion Male liver damage is more than females in Libo,and the middle- age group is also greater than the low- age group and high- age group. while the immunity for HBV infection of low- age group is greater than the middle- age group and high- age group. In order to block the spread of HBV,early prevention and timely treatment should be performed combining with the liver function index to improve the health status of the population.

关 键 词：荔波 肝功能 乙型病毒性肝炎 

分 类 号：R512.62[医药卫生—内科学]